Menopause Flashcards
Climacteric
Phase in a woman’s reproductive life when a gradual decline ovarian fxn results in decreased sex steroid production, and the associate sequelae
Menopause transition
change in length
increase FSH
leading to FMP
Perimenopause
change in length
increase FSH
12 months after FMP
Menopause
12 months of amenorrhea after FMP in a woman >45 yo in absence of other biological/physiological causes
Postmenopause
early stage is first 5 yrs after FMP, late stage is 5 yrs after FMP to death
Nl age of menopause and contributing factors to age of onset
50-55, avg 51.5
-genetics, smoking, hysterectomy
Sx of perimenopause
- changes in menstrual cycles
- mood and emotional changes
- hot flashes or flushes and night sweats
- breast changes
What happens to estrogen, androgens, progesterone, LH, and FSH levels in menopause?
- decreased estrogen
- decreased androgens (facial hair growth, decreased breast size)
- decreased progesterone (irregular vaginal bleeding)
-Increased LH and FSH
General sx of menopause
- hot flushes
- insomnia
- irritability
- mood disturbances
physical changes of menopause
- urogenital atrophy
- urinary stress incontinence
- skin collagen loss
disease a/w menopause
- osteoporosis
- CV disease
- dementia
Describe sx of “genitourinary syndrome of menopause”
- vaginal atrophy
- vaginal canal shrinks in diameter
- elastic capacity of the bladder is decreased
What are 1st and 2nd line tx options for menopause?
1ST line= non-hormonal vaginal moisturizers and lubricants
2nd= vaginal estrogen therapy
What is the gold standard tx for patients for relief of vasomotor sx?
Estrogen therapy
Who should NOT have unopposed estrogen?
women w/ a uterus
also: breast CA, CHD, prior stroke, high risk endometrial CA