Meningitis and encephalitis Flashcards
1
Q
Antibodies in non paraneoplastic encephalitis
A
NMDA receptor Abs- a/w ovarian teratoma- Psychiatric features,altered sleep-wake,respiratory depression,oro facial movement disorder
VGKC abs- now LGI1 and CASPR 2
2
Q
Paraneoplastic abs in encephalitis
A
Limbic encephalitis-Hu abs -lung CA
Ma abs- testicular CA
Yo abs -cerebellar degeneration
Anti-amphiphysin -breast CA
3
Q
Stiff person syndrome
A
Anti-GAD
4
Q
CADASIL features
A
Migraine with aura -20-40%
CVA -65-80% mean age 50
Dementia
MRI -anterior temporal ,external capsule changes
5
Q
Genetics in CADASIL
A
Notch 3 mutation
Skin biopsy -osmophilic granules
6
Q
PRES features
A
Headache, confusion ,seizures, visual loss
Conditions associated: Malignant HTN,eclampsia, transplant (tacrolimus, cyclosporine)
