Meningitis Flashcards
Definition
Inflammation of the membranes covering the brain & spinal cord.
Types: - Bacterial
- Aspetic e.g. viral → most common, fungal
- Tuberculous
Bacterial (Septic) meningitis
Causes more then 1m
Pneumococci
Staphylococci
Streptococci
Nisseria meningitides
Acute Bacterial Meningitis
.neonat
y E.coli
y Listeria monocytogenes
y Hemophilus influenza.
Transmission /Bacterial (Septic) meningitis
Droplet infection mostly (Blood borne in neonatal sepsis)
Clinical picture/Non specific
- High fever (may be hypothermia in neonates).
- Poor feeding
• Rose spots may appear on the trunk & extremities in meningeococcal septicemia.
. irritability, restlessness, depressed mental status
Features of increased intracranial pressure (ICP)
- Before fontanel closure p tense, bulging anterior fontanel
- After closure of fontanels:
Severe bursting headache (irritability)
Blur of vision
Projectile vomiting (in the morning, not preceded by nausea)
😱Cushing response (hypertension & bradycardia)
Features of meningeal irritation: (less sensitive in infants)
- Neck rigidity (stiffness) p limited neck flexion
- Opisthotonus p arched back
- Kernig’s sign p inability to extend the leg after the thigh is flexed to a right angle with the axis of the trunk.
- Brudzinski leg sign: Passive flexion of one hip p flexion of the other hip and knee
- Brudzinski neck sign: Passive flexion of the neck p flexion of the hip & knee.
Neurologic signs
• Stupor & drowsiness
• Convulsions ➡️ usually generalized
😓 Coma
Complications
1- Syndrome of inappropriate secretion of antidiuritic hormone (SIADH) p so, maintenance fluids must be at 2/3 normal to avoid brain edema.
2- Neurologic complications:
- Increased intracranial pressure (ICP) p May leads to cerebral or cerebellar herniation
- Subdural effusion
- Cranial nerve lesions (commonly oculomotor, 6 th & 8 th nerves).
- Hydrocephalus.
3- Peripheral circulatory complications
i- Waterhouse Friedrichson syndrome
- Septicemia
- Shock
- Extensive purpura
- Adrenal hemorrhage (acute adrenal failure).
ii- DIC: Gangrenous patches & extremities
4- Dissemination of infection: endocarditis, arthritis , osteomyelitis
Investigations in the bacterial form
- CBC➡️⬆️PMNL
- Blood culture reveals the responsible bacteria in up to 80-90% of cases
- C-reactive protein, ESR, and procalcitonin have been used to differentiate bacterial (usually elevated) from viral causes of meningitis
- Lumbar puncture (LP) & CSF examinations
Lumbar puncture (LP) & CSF examinations/Value
-Diagnostic➡️organism,⬆️PMNL, ⬆️ protein,⬇️glucose, Turbid fluid
- Determine appropriate antibiotics by culture & sensitivity.
- Evaluate treatment: CSF become sterile within 24- 48 hours of appropriate antibiotics
Lumbar puncture (LP) & CSF examinations/Contraindications for an immediate LP
- Evidence of increased ICP (other than a bulging fontanel), such as 3rd or 6th cranial nerve palsy with a depressed level of consciousness, or hypertension and bradycardia with respiratory abnormalities
- Severe cardiopulmonary compromise requiring prompt resuscitative measures for shock
- Infection of the skin overlying the site of the LP
Lumbar puncture (LP) & CSF examinations -What to do if an LP is delayed?
- Initiate empirical antibiotic therapy
_ CT scanning for evidence of a brain abscess or increased ICP - LP may be performed after increased ICP has been treated
CSF in Viral meningitis
Clear,,⬆️protein,N. Glucose,⬆️ mononuclear cells predominate
In partially treated meningitis
: Culture and gram stain are usually negative
: But Pleocytosis with a predominance of neutrophils, elevated protein level, and a reduced CSF glucose usually persist for several days