MEN Flashcards
Definition
Functioning hormone tumours in multiple organs All autosomal dominant
MEN1
Pituitary adenoma: prolactin or GH
Parathyroid adenoma / hyperplasia
Pancreatic tumours: gastrinoma or insulinoma
MEN2
Thyroid medullary carcinoma
Adrenal phaeochromocytoma
A) Hyperthyroidism
B) Marfanoid habitus
What are neurofibromatosis signs
Dermal neurofibromas Café-au-lait spots
Lisch nodules
Axillary freckling
Phaeochromocytoma
Von Hippel-Lindau
Renal cysts Bilateral renal cell carcinoma Haemangioblastomas Often in cerebellum → cerebellar signs Phaeochromocytoma Pancreatic endocrine tumours
Peutz-Jeghers
Mucocutaneous freckles on lips, oral mucosa and palms / soles
GI hamartomas: obstruction, bleeds
Pancreatic endocrine tumours
↑ risk of cancer: CRC, pancreas, liver, lungs, breast
Carney complex
Lentigenes: spotty skin pigmentation
Differential: Peutz-Jehgers Atrial Myxoma
Endocrine tumours: pituitary, adrenal hyperplasia Schwannomas
(LAME Syndrome)