MEN Flashcards

1
Q

Definition

A

Functioning hormone tumours in multiple organs All autosomal dominant

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2
Q

MEN1

A

Pituitary adenoma: prolactin or GH
Parathyroid adenoma / hyperplasia
Pancreatic tumours: gastrinoma or insulinoma

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3
Q

MEN2

A

Thyroid medullary carcinoma

Adrenal phaeochromocytoma
A) Hyperthyroidism
B) Marfanoid habitus

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4
Q

What are neurofibromatosis signs

A

Dermal neurofibromas Café-au-lait spots
Lisch nodules
Axillary freckling
Phaeochromocytoma

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5
Q

Von Hippel-Lindau

A
Renal cysts
  Bilateral renal cell carcinoma
  Haemangioblastomas
  Often in cerebellum → cerebellar signs
  Phaeochromocytoma
  Pancreatic endocrine tumours
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6
Q

Peutz-Jeghers

A

Mucocutaneous freckles on lips, oral mucosa and palms / soles
GI hamartomas: obstruction, bleeds
Pancreatic endocrine tumours
↑ risk of cancer: CRC, pancreas, liver, lungs, breast

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7
Q

Carney complex

A

Lentigenes: spotty skin pigmentation
Differential: Peutz-Jehgers Atrial Myxoma
Endocrine tumours: pituitary, adrenal hyperplasia Schwannomas

(LAME Syndrome)

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