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Endocrinology > HypoPTH > Flashcards

HypoPTH Flashcards

1
Q

Cause

A

↓PTH due to gland failure

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2
Q

Presentation: SPASMODIC

A 
SPASMODIC
  Spasms (carpopedal = Trousseau’s sign)
  Perioral paraesthesia
  Anxious, irritable
  Seizures
  Muscle tone ↑→ colic, wheeze, dysphagia
  Orientation impaired (confusion)
  Dermatitis
  Impetigo herpetiformis (↓Ca + pustules in pregnancy)   Chovsteks, cardiomyopathy (↑ QTc → TdP)
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3
Q

Causes - autoimmune, congenital, iatrogenic

A

Autoimmune

  Congenital: DiGeorge
  Cardiac abnormality: Fallot’s   Abnormal facies
  Thymic aplasia
  Cleft palate
  Hypocalcaemia
  Chr 22
  Iatrogenic

Surgery Radiation

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4
Q

Investigation results

A

↓Ca, ↑PO4, ↓PTH, normal ALP

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5
Q

Treatment

A

Ca supplements

Calcitriol

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6
Q

What is Pseudohypoparathyroidism, investigations, treatment?

A

Failure of target organ response to PTH
Symptoms of hypocalcaemia
Short 4th and 5th metacarpals, short stature

Ix: ↓Ca, ↑PTH
Rx: Ca + calcitriol

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7
Q

What is Pseudopseudohypoparathyroidism

A

Normal (maternal) receptor in kidney → normal biochem

Abnormal (paternal) receptors in body → pseudohypoparathyroidsm phenotype

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Endocrinology (16 decks)

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