Diabetes insipidus Flashcards
1
Q
Symptoms
A
Symptoms Polyuria Polydipsia Dehydration Hypernatraemia: lethargy, thirst, confusion, coma
2
Q
Cranial causes
A
Idiopathic: 50% Congenital: DIDMOAD / Wolfram Syndrome Tumours Trauma Vascular: haemorrhage (Sheehan’s syn.) Infection: meningoencephalitis Infiltration: sarcoidosis
3
Q
Nephrogenic causes
A
Congenital
Metabolic: ↓K, ↑Ca
Drugs: Li, demecleocycline, vaptans
Post-obstructive uropathy
4
Q
Ix
A
Bloods: U+E, calcium, glucose
Urine and plasma osmolality
Exclude DI if U:P osmolality >2
5
Q
Differential Ix
A
Water deprivation test ̄c desmopressin trial
6
Q
Differential Dx
A
DM
Diuretics or Lithium
Primary polydipsia
7
Q
Cranial treatment
A
Find cause: MRI brain
Desmopressin PO
8
Q
Nephrogenic Rx
A
Treat cause
