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INTERNAL MEDICINE 5TH > MEN > Flashcards

MEN Flashcards

1
Q

MEN TYPE 1

A

Parathyroid: hyperplasia/adenomas
Pancreas: gastrinoma, insulinoma
Pituitary: prolactinoma

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2
Q

MEN TYPE 2 b

A

hyroid: medullary thyroid cancer
Adrenal: pheochromocytoma
Parathyroid: hyperplasia/adenomas
Mucosal neuromas

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3
Q

MEN TYPE 2A

A

Thyroid: medullary thyroid cancer
Adrenal: pheochromocytoma
Parathyroid: hyperplasia/adenomas

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4
Q

signs of hypeparathyroidsm

A

bon pain - osteoclasts
stones
high calcium levels

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5
Q

type 1 APS

A

mucocutnaous candiais
primary adrenal insufficiency
hypoparthathyroidism

others such as ectodermal dystrophy relating to brittle nails, and enamel of teeth , alopenic , vitiligo

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6
Q

type 2 APS

A

type 1 DM
Addisons disease
autoimmune thyroid disease (hypothyroidism)

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7
Q

what to exclude in a patient with primary hyperparathyroidism

A

MEN 1 - these patients usall have multiple

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8
Q

which is the most common MEN1 pituitary adenoma

A

Lactotrophs (usually single) and macro is more common than micro

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9
Q

cabergoline and bromocriptine

A

ARE DOPAMINE AGONISTS and we use to reduce the prolactin and its inhibitory on dopamine

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10
Q

tx FOR MEN 1

A

symptomatic and definitive

symptomatic

PPI’S- Zollinger
Dopamine agonists for prolactin
cincalcet - for hyperthyroidism
surgery - for tumours

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11
Q

whats the inheritance pattern of MEN

A

DOMINANT - all so far

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12
Q

gene affected in MEN 2

A

RET gene

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13
Q

what is 100% expected in mEN 2

A

medullary thyroid carcinoma !

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14
Q

which subset has mucosal neuromas

A

men type 2 b

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15
Q

APS TYPE 1 which gland is first to be affected

A

parathyroid glands

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16
Q

gene of APS type 1

A

AIRE - autoimmune regulatory

17
Q

what kind of disease is APS type 2

A

automiimne

18
Q

diagnosi sciatteria

A

at least 2/3

19
Q

whats usually the first sign of APS 1

A

mucocutnaous candiadis(babies) but first Endo gland is parathyroid

20
Q

APS TYPE 3 (double check)

A

A- automimmun thyroiditis + DM
B- …..+ pernicious
C- ……+ vitiligo/alopecia

INTERNAL MEDICINE 5TH (12 decks)

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