Memory mechanisms at the cellular and network level Flashcards
1
Q
What does an engram refer to?
A
The lasting physical changes in brain state and structure that occur in response to an event or experience
- memory-encoding neural ensambles
- cell assemblies
- memory traces
2
Q
What are the three main types of memory?
A
- emotional
- declarative
- non-declarative
3
Q
What does the hippocampus play a role in (london taxi drivers)?
A
Spatial navigation
4
Q
Describe the hippocampal formation.
A
- denate gyrus
- CA3-1
- subiculum
5
Q
What are principle cells?
A
- The soma is located far away from the projection
6
Q
Describe the principle cells in the HF.
A
- found in DG, CA3, CA1 and subiculum
- all interconnected, forming a loop
- all excitatory
7
Q
Describe basket cells.
A
- interneurons
- project near the soma
- fast spiking
- feed-forward inhibition
- pavalbumin expression
8
Q
Describe Oriens-lacunosum moleculare cells (O-LMC).
A
- interneurons
- project to distal dendrites
- feed-back inhibition
- somatostatin expression
9
Q
Describe interneurons.
A
Inhibitory (GABAergic), local projection neurons that regulate the excitability of networks
10
Q
What are place cells?
A
- cells that fire in a specific region of an environment
- info of where you are in space
11
Q
What are the place of origin of the place signal?
A
Grid cells in the entorhinal cortex
12
Q
A
