Memory Flashcards

1
Q

What is the definition of learning?

A

Acquisition of information

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2
Q

What is the definition of memory?

A

Storage of learned information

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3
Q

What is the definition of recall?

A

Reaquisition of stored information

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4
Q

What is the definition of engram?

A
  • Physical embodiment of memory

hypothetical permanent change in the brain accounting for the existence of memory; a memory trace

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5
Q

What is procedural memory?

A

Learnt skills and associations largely UNAVAILABLE to the conscious mind
- Eg. habits, mannorisms, playing the piano

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6
Q

What is declarative memory?

A
  • AVAILABLE to the conscious mind
  • Can be encoded in symbols and language
  • Can be transmitted to somebody else
  • Eg. events that have happened, information
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7
Q

How is memory classified?

A

On how long a memory lasts:

  • Immediate: a few seconds
  • Short term: seconds or minutes. Involves ‘working memory which is problem solving.
  • Long term : days, months, years
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8
Q

Where is working memory held?

A

In the pre-frontal cortex

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9
Q

What is the involvement of the hippocampus in memory?

A
  • Converts short-term memory into long-term memory

- Majority is declarative

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10
Q

What is the involvement of the amygdala in memory?

A
  • Processes multiple SENSORY inputs (eg. smell) either directly or indirectly
  • Activated by implicit/ emotional/ learnt fear
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11
Q

What is the involvement of the cerebellum in memory?

A
  • Procedural memory

- Sensorimotor skills (both motor and sensory

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12
Q

What does hippocampal lesions cause?

A
  • Cause memory loss and inability to lay down new memories

- But can still recall old memories

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13
Q

What are they layers in the hippocamupus and how is this different to the rest of the cortex?

A

3 layers:

  • Polymorphic
  • Pyramidal
  • Molecular

Rest of the cortex has 6 layers

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14
Q

What are the 4 sections of the hippocampus?

A

1) Dentate gyrus

2) Cornu ammonois
- CA1 to CA4

3) Subiculum
4) Parahippocampal gyrus

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15
Q

Where do the inputs into the hipocampus come from?

A

The entorhinal complex and beyond

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16
Q

What are outputs from the hippocampus via?

A

The fornix

17
Q

How is long term memory stored?

A

It is distributed - stored in many areas of the brain

18
Q

What is the Hebbian synapse concept?

A
  • Memory is stored at a cellular level at synapses
  • Synapses become stronger/weaker based upon previous experience
  • Activity modifiable
19
Q

What circuits are used in memory?

A

Reverberating circuits

- Stimulation with the right input will lead to memory reappear

20
Q

What is synapse plasticity?

A

Synapse strength can change in response to increases or decreases in its stimulation:
Facilitated = stronger
Depressed = weaker
- Can be either long-term or short-term

21
Q

What is LTP? Describe the process

A
  • Long term potentiation (increase strength of nerve impulses)
  • Cells in CA3 send schaffer collaterals (processes) to cells in the CA1 region
  • CA1 can inputs from many cells in the CA3 region
  • The CA3 inputs can be experimentally stimulated by post-tetanic LTP or paired LTP
22
Q

What causes the short-term change in synapse strength?

A
  • Ca2 avalibility

- Vesicle depletion

23
Q

What is post-tetanic LTP?

A
  • High frequency stimulation of the pre-synaptic neurons (pre-tetanic)
  • Input specific
  • Stimulate pathway 1 results in an increase in the EPSP generated in the post-tetanic
  • Stimulate pathway 2 results in no change in EPSP generated in post-tetanic
24
Q

What is paired LTP?

A
  • Stimulation of the target cell directly (CA1 as well as the schafffer collaterals
  • Leads to a strengthening of the CA1 response
  • Coincident stimulus and direct depolarisation
  • Strengthening can occur if the two inputs are received at the same time
25
Q

What does the gill withdrawal reflex show?

A
  • Habituation (reduced respomse with multiple exposurs over time)
  • Short and long term sensitisation