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Immunology Exam Two > Memory > Flashcards

Memory Flashcards

1
Q

What is the most important biological consequence of adaptive immunity?

A

Immunological memory

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2
Q

What are the longest lived antibodies?

A

IgG

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3
Q

How long do the longest lived antibodies live?

A

Month or two

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4
Q

What are the three kinds of B cells?

A

Short-lived plasma cell, long-lived plasma cell (memory cell), central memory B cell

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5
Q

What is required in order for the generation of both kinds of memory B cells to occur?

A

T cell help

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6
Q

What are the two kinds of memory B cells?

A

Long-lived plasma cell, central memory B cell

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7
Q

Where are short-lived plasma cells formed?

A

Lymphoid follicles of secondary lymphoid organs

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8
Q

What is the function of short-lived plasma cells?

A

Produce incredible amounts of antibodies

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9
Q

What is the life span of short-lived plasma cells?

A

Few days

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10
Q

To where do short-lived plasma cells travel?

A

Bone marrow and spleen

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11
Q

Where are long-lived plasma cells produced?

A

Lymphoid follicles of secondary lymphoid organs

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12
Q

To where do long-lived plasma cells travel to and take up residence?

A

Bone marrow

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13
Q

What is the function of long-lived plasma cells?

A

Continuously produce modest amounts of antibodies

Provide life-long antibody protection

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14
Q

Which B cell is used for measuring titers?

A

Long-lived plasma cells

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15
Q

Why do long-lived plasma cells live longer?

A

They aren’t worked as hard

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16
Q

Which make more antibodies: short or long-lived plasma cells?

A

Short-lived

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17
Q

What kind of B cells function as memory stem cells?

A

Central memory B cells

18
Q

Where do central memory B cells reside?

A

Mainly in secondary lymphoid organs

19
Q

What kinds of cells replace long-lived plasma cells when they die from old age?

A

Central memory B cells

20
Q

If an invader is encountered again, what do central memory B cells do?

A

Quickly proliferate and make more short-lived plasma B cells

21
Q

Do central memory B cells usually quickly proliferate?

A

No; usually slowly unless in the presence of previous invader

22
Q

Which kind of B cell provides life-long antibody protection?

A

Long-lived plasma cell

23
Q

What kind of T cells travel to a battle site and fight?

A

Effector T cells

24
Q

What kind of memory T cells travel to a battle site and remain there?

A

Memory effector T cells

25
Q

What kind of activated T cells stay in the secondary lymphoid organs and bone marrow after activation?

A

Central memory T cells

26
Q

What happens to central memory T cells during subsequent attacks?

A

Quickly activate and proliferate mostly into effector T cells, then go to battle site

27
Q

Which are easier to activate: memory B and T cells or naive B and T cells?

A

Memory B and T cells

28
Q

Why is somatic hypermutuation of memory B cells important?

A

Creates better antibody receptors fit to the invader for an “upgraded” fight

29
Q

Why is class switching of memory B cells important?

A

Remains imprinted on the memory B cell to be better suited for the invader

30
Q

What type of memory cells are fine tuned through somatic hypermutation?

A

B memory cells

31
Q

What type of memory cells make antibodies?

A

Memory B cells

32
Q

What type of memory cells are dormant?

A

Memory T cells

33
Q

Why is it important that memory T cells remain dormant unless the invader is present?

A

T cells would make chemistry and kill things (not good if not killing an invader)

34
Q

Why are antibodies safe to have readily made and “lying around”?

A

They don’t have the ability to kill and are therefore harmless (like T cells do)

35
Q

What is the T cell equivalent to a long-lived plasma B cell?

A

There isn’t one!

36
Q

What type of memory is static: innate or adaptive?

A

Innate (doesn’t update)

37
Q

All humans have essentially what kind of memory?

A

Innate

38
Q

What type of memory is expandable and dynamic?

A

Adaptive

39
Q

What determines a human’s adaptive memory?

A

Invaders that are encountered

40
Q

Do two people that encounter the same antigen have the same adaptive memory?

A

NO

41
Q

Why do two people that encounter the same antigen develop different adaptive memories?

A

Different TCRs and BCRs (not an exact match)

42
Q

Is it possible that 2 humans have the exact same adaptive memory?

A

NO NO NO

Immunology Exam Two (5 decks)

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