Membranes Flashcards
The structure of membranes depends on ___
- Fluidity
- Functional proteins
What are membranes mainly composed of?
Proteins
Accepted model of membranes
Fluid Mosaic
Several lipids within membranes
- Phospholipids
- Glycolipids
- Sterols
Rotation and lateral diffusion
Rapid and random
Transverse diffusion
Rare and regulated
Transition temperature (Tm)
The temperature of which a lipid bilayer becomes fluid
Effects of chain length on Tm
Longer fatty acid chains decrease membrane fluidity
Effects of unsaturation on Tm
Double bonds in unsaturated fatty acids increase fluidity
Fluidity Buffer
Maintains membrane fluidity in response to changes in temperature
Homeoviscous Adaptation
Change in length and degree of saturation of fatty acids to compensate for temperature changes
Lipid Rafts
Localized micro-domains of membrane lipids with specific proteins
- Low fluidity
3 categories of membrane proteins
- Integral membrane proteins
- Peripheral proteins
- Lipid-anchored proteins
Integral membrane proteins
Embedded in lipid bilayer
- Have hydrophobic domains
Peripheral proteins
Located on one side of the bilayer
Lipid-anchored proteints
Covalently attached to lipid molecules embedded in the bilayer
Glycosylation
Linkage of a carbohydrate to a protein
Glycoproteins
Prominent in plasma membranes
- Important for cell-cell recognition and signaling