mem Flashcards
State sympathetic functions
mydriasis - dilation bronchodilation tachycardia - inc HR vasoconstriction - inc BP dec GI motility - relaxed glucose released decrease blood flow to skeletal muscle
State parasympathetic functions
miosis - constriction bronchoconstriction bradycardia - dec HR DO NOT SUPPLY VESSELS inc GI motility - contraction \+ secretions
MERKELL CELL
SA1
hairy + glaborous
small RF
sustained response
MEISSNER CORPUSCLE
RA1 glaborous small RF lost response Account for human sensitivity to low frequency vibrations best detects lateral motion stimulus
RUFFINI ENDING
SA2 hairy + glaborous large RF sustained response Primarily sensitive to skin stretch
PACINIAN CORPUSLCE
RA2 hairy + glaborous large RF lost response best detects vibration stimulus
Pyramidal motor neuron development steps
Neural induction Neurulation Neurogenesis Neural migration Neural patterning Axon growth/guidance Synaptogenesis Gliogenesis
Why do we use organoids
can be made into neural tissue with stem cells
self organising so can watch development
can look at specific mutations
cannot look at vascularisation or immune system
Sympathetic ganglion neuron development steps
neural crest induction epithelial-mesenchymal transition neural crest migration aggregation into ganglia axon guidance synaptogenesis
explain neurogenesis and neural migration
progenitor cells proliferate to neuroblasts
divide at ventricular surface
symmetric = 2 progenitor, asymmetric = neuron + prog
neuroblasts from apical surface migrate to cortex
from cortex inside out manner
what electro physical properties are developed
develop early, undergo maturation
produce detailed APs from channels instead of Ca spikes
where do specific glial cells develop from
astrocytes + oligo develop from neural plate
microglia develop from immune system
what does neural crest form
most of PNS
dorsal root
sympa, para ganglia
enteric system
parts of face
Adrenal medullary cells derived from neural crest
The nicotinic receptors developed from the neural crest
describe aggregation into ganglia
cell dispersed along aorta aggregate into discrete ganglia
sympa ganglia move to more dorsal position
Visual cortex
parallel = change in RF size
