Melanoma Flashcards

1
Q

Mole V melanoma check?

A
ABCDE Checklist
Asymmetry
Border (irregular/indistinct)
Colour (varied)
Diameter (inc or >6mm)
Enlargement/elevation/evolution
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is lentigo maligna?

A

Malignant melanoma in situ (normal and malignant melanocytes confined to the epidermis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Appearance lentigo maligna?

A

2-6cm tan/brown/black uniformly flat macule or patch with irregular borders. Lesions grow radially and produce complex colours.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Malignant transformation of lentigo maligna?

A

10% evolve into lentigo maligna melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is lentigo maligna melanoma?

A

15% of all melanomas.

Malignant melanocytes invading into the dermis. A/w pre-existing solar lentigo, not pre existing naevi.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Appearance lentigo maligna melanoma?

A

Flat brown stain like gradually enlarging. Changes from uniform brown to dark brown with black and blue over time.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is superficial spreading melanoma?

A

60-70% melanomas.

Atypical melanocytes initially spreading laterally in epidermis then invade dermis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Appearance superficial spreading melanoma?

A

Irregular, indurated, enlarging plaques with r/w/b discolouration, focal papules or nodules. Ulcerate and bleed with growth.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is a nodular melanoma?

A

Atypical melanocytes that initially grow vertically with little lateral spread.
“EFG”: elevated, firm, growing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Appearance nodular melanoma?

A

Uniformly ulcerated, blue-black, sharply delineated plaque or nodule. May be pink or colourless (amelanotic melanoma)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is an acrolentiginous melanoma?

A

5% of melanomas.

Ill-defined dark brown, blue-black macule on palmar, plantar or subungal skin.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

RFx for melanoma?

A

No SPF is a SIN

  • Sun exposure
  • Pigment traits (blue eyes, fair skin)
  • Freckling
  • Skin reaction to sunlight (increased incidence of sunburn)
  • Naevi (dysplastic naevi)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Pathophysiology of melanoma?

A

Malignant neoplasm of pigment forming cells (melanocytes and naevus cells).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Common sites of melanoma?

A
  • Back (M)

- Calves (F)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Factors indicating worse prognosis in melanoma?

A
  • Male
  • On scalp, hands, feet
  • Late lesion
  • No pre-existing naevus present
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Mx melanoma?

A

Excisional biopsy; remove full depth of dermis and extend beyond edges of lesion only after histologic diagnosis.
-High does IFN for stage II-III disease.