Melanoma

Question 1

Mutaciones en Melanoma

Answer 1

BRAF, CDKN2A, CDK4

Question 2

Estirpe histologica más frecuentes

Answer 2

1. Lentiginoso Acral (MEXICO)
2. Nodular
3. Amelanotico
4. Extension superficial

Question 3

Metastasis

Answer 3

1. Pulmón
2. Hígado
3. SNC

Question 4

Breslow

Answer 4

MM

Question 5

Clarke

Answer 5

Capas

Question 6

Dermatoscopia

Answer 6

Reticular atípico
Glóbulos irregulares
Areas azul-blanquecinas

Question 7

Inmunohistoquimica

Answer 7

S-100
HMB-45
Melan-A

Question 8

Tratamientos medicos

Answer 8

Inhibidores PD-1
Inhibidores CTLA-4
Inhibidores BRAF V600

Question 9

Inhibidores
PD-1

Answer 9

Pembrolizumab
Nivolumab

Question 10

Inhibidores
CTLA-4

Answer 10

Ipilimumab

Question 11

Inhibidores
BRAF V600

Answer 11

Vemurafenib
Dabrafenib

Question 12

Inhibidores
MEK

Answer 12

Trametinib

Question 13

Interferon Alfa

Answer 13

Recurrencia posterior a cirugia

Question 14

Terapia oncolitica viral

Answer 14

Talimogene Laherparepvec
(T-VEC)

Question 15

T-VEC

Answer 15

Metastasis no resecable

Question 16

Inhibidores PD-1

Answer 16

Pembrolizumab, Nivolumab
Disminuye riesgo recurrencia post reseccion

Question 17

Efectos secundarios de inmunoterapia

Answer 17

colitis
hepatitis
neumonitis

Question 18

Toxicidad por Inhibidores de punto de control

Answer 18

Corticoesteroides en dosis alta

Question 19

Margen quirurgico

Answer 19

0.5 cm para melanoma in situ

Question 20

Margen quirurgico segun invasion por Breslow

Answer 20

<1 mm: 1 cm
1-2 mm: 1-2 cm
>2 mm: 2 cm

Question 21

Biopsia de ganglio centinela (Indicacion)

Answer 21

Breslow >0.8 mm
Breslow <0.8 mm con alto riesgo

Question 22

Biopsia de ganglio centinela (Utilidad)

Answer 22

Micrometastasis

Question 23

Identificacion de Biopsia de ganglio centinela

Answer 23

Linfogammagrafia

Question 24

Criterios Linfadenectomia completa

Answer 24

No recomendado, priorizar seguimiento por USG