Meglitinides

Question 1

Meglitinides end in what suffix?

Answer 1

-glinide

Question 2

What is the MOA of meglitinides?

Answer 2

Stimulate insulin secretion by beta cells

Question 3

Meglitinides work similarly to sulfonylureas but with a __________ onset and a __________ duration of action

Answer 3

Faster onset
Shorter duration

Question 4

Meglitinides expected change in A1c

Answer 4

High

Question 5

Meglitinides route of administration

Answer 5

Oral

Question 6

Meglitinides ADEs

Answer 6

Hypoglycemia
Especially with renal impairment

Question 7

Meglitinides have a ___________ incidence of hypoglycemia than sulfonylureas

Answer 7

Lower

Question 8

Meglitinides risk of hypoglycemia

Answer 8

High

Question 9

Do Meglitinides cause weight gain or loss?

Answer 9

Gain

Question 10

Meglitinides CV impact

Answer 10

Unknown

Question 11

Meglitinides renal impact

Answer 11

Unknown

Question 12

Meglitinides precautions/CIs

Answer 12

Hepatic dysfunction

Question 13

Meglitinides drug interactions

Answer 13

CYP450 system
Gemfibrozil

Question 14

Meglitinides dosing needs to be adjusted based on?

Answer 14

Size of meal
Post-prandial glucose

Question 15

Meglitinides should be taken before, with, or after meals?

Answer 15

With

Question 16

Cost of Meglitinides

Answer 16

Low