Meglitinides Flashcards
Meglitinides end in what suffix?
-glinide
What is the MOA of meglitinides?
Stimulate insulin secretion by beta cells
Meglitinides work similarly to sulfonylureas but with a __________ onset and a __________ duration of action
Faster onset
Shorter duration
Meglitinides expected change in A1c
High
Meglitinides route of administration
Oral
Meglitinides ADEs
Hypoglycemia
Especially with renal impairment
Meglitinides have a ___________ incidence of hypoglycemia than sulfonylureas
Lower
Meglitinides risk of hypoglycemia
High
Do Meglitinides cause weight gain or loss?
Gain
Meglitinides CV impact
Unknown
Meglitinides renal impact
Unknown
Meglitinides precautions/CIs
Hepatic dysfunction
Meglitinides drug interactions
CYP450 system
Gemfibrozil
Meglitinides dosing needs to be adjusted based on?
Size of meal
Post-prandial glucose
Meglitinides should be taken before, with, or after meals?
With