2nd Gen Sulfonylureas Flashcards
What are the 3 available 2nd gen sulfonylurea agents?
Glipizide
Glyburide
Glimepiride
What is the MOA for 2G sulfonylureas?
Stimulate insulin secretion from beta cells
What is the expected change in A1c for 2G sulfonylureas?
High
What is the route of administration for sulfonylureas?
Oral
What are the ADEs of sulfonylureas?
Hypoglycemia
Especially w/ renal impairment
What are sulfonylureas risk of hypoglycemia?
High
Do sulfonylureas cause weight gain or loss?
Gain
What are sulfonylureas impact on CV health?
No impact
What are sulfonylureas impact on renal function?
Neutral
Precautions/CIs of sulfonylureas
Renal dysfunction
Hepatic dysfunction
Use low does for elderly
Atypical antipsychotics and/or corticosteroids increase or reduce the efficacy of sulfonylureas?
Reduce
(increase blood sugar)
Azole antifungals and clarithromycin increase or reduce the efficacy of sulfonylureas?
Increase
(decrease blood sugar)
Sulfonylurea dosage is adjusted based on?
Size of meal
Post-prandial glucose
What is the cost of sulfonylureas?
Low
