Megaloblastic anaemia

Question 1

Macrocytic anaemia

Answer 1

Anaemic state with presence of abnormally large RBC (high MCV in blood)

Question 2

Megaloblast

Answer 2

Abnormally large immature erythryoblast found in bone marrow

Question 3

Megaloblast formation is caused by?

Answer 3

Vitamin B12 or Folate deficiency

Question 4

Vitamin B12 and Folate are required for?

Answer 4

DNA synthesis

Question 5

Deficiency of Vitamin B12 and folate causes?

Answer 5

Abnormal cellular maturation

Question 6

Lack of vitamin b12 and folate affects cytoplasm how?

Answer 6

Cytoplasm to nucleus ratio becomes very high (stuck in growth phase)

Question 7

Vitamin b12 and folate deficiency affects erythryoblasts how?

Answer 7

Erythryoblasts become large, oval-shaped with small immature nucleus

Question 8

Megaloblasts causes __________ leading to macrocytic anaemia

Answer 8

Dysplastic erythryopoiesis

Question 9

Pernicious anaemia definition

Answer 9

Anaemia from an autoimmune disorder which targets gastric cells and reduced intrinsic factor, leading to vitamin B12 deficiency

Question 10

Vitamin b12 deficiencies such as diet should not be confused with pernicious anaemia

Answer 10

True

Question 11

Pernicious anaemia’s mechanism

Answer 11

• Body produces auto-antibodies against gastric cells in stomach
• Gastric cells have reduced synthesis of intrinsic factor
• Intrinsic factor required to bind with vitamin b12 for absorption by ileum.

Question 12

Poor vitamin b12 absorptions leads to?

Answer 12

Macrocytic anaemia

Question 13

Pernicious anaemia is associated with?

Answer 13

Glossitis