Megaloblastic Anaemia

Question 1

Where is the absorption site for Vitamin B12?

Answer 1

Ileum

Question 2

Where is the absorption site for Folate?

Answer 2

Duodenum and Jejunum

Question 3

What are the causes of Megaloblastic anaemia?

Answer 3

1. Vitamin B12 Deficiency
2. Folate Deficiency
3. Abnormalities of vitamin B12 or folate metabolism (e.g. transcobalamin deficiency, nitrous oxide, antifolate drugs)
4. Other defects of DNA synthesis-
   * Congenital enzyme deficiencies (e.g. orotic aciduria)
   * Acquired enzyme deficiencies (e.g. alcohol, therapy with hydroxyurea, cytosine arabinoside

Question 4

Fill in the blanks. “ Most B12 is plasma is bound to another protein named __________ (also called _____________).

Answer 4

Haptocorin also called Transcobalamin I

Question 5

Transcobalamin I ( Haptocorin) is produced by?

Answer 5

Granulocytes and macrophages