Inflammatory Disease of Lymph Nodes Flashcards
Where do all lymphoid cells originate?
In the Bone Marrow
What type of cells are found in the Superficial cortex/ Cortical Area?
Predominantly B cells - Humoral immunity:
antibody-mediated
response
Fill in the blanks. “ Primary follicles
become secondary
follicles when
stimulated by ___________.”
Antigens
Lymphoid follicles with
their germinal centres are found in which are of the lymph node?
Superficial cortex/ Cortical Area
What type of cells are found in the Deep Cortex / Paracortical Area?
- Predominantly T-cells
*Postcapillary venules and
interdigitating cells
What is the name given to the site of lymphocytic migration from the blood into lymphocytic tissue?
Post-capillary Venules
What is the main site of Plasma Cell proliferation, differentiation and production of antibodies?
Medulla / Medullary Area
What type of cells are found in the Medulla/ Medullary Area?
- Lymphocytes
- Plasmacytoid
lymphocytes - Plasmablasts and
mature plasma cells in varying proportions
What type of cells are found in the Sinuses of lymph nodes?
Active macrophages & Histicoytes
What is the function of the sinuses of lymph nodes?
Transport lymph fluid from the
afferent lymphatics through the
lymphoid parenchyma into the
efferent lymphatics in the lymph
node hilus.
What is the main route for incoming lymphocytes?
Blood Vessels
What is lymphadenopathy?
Disease or swelling of the
lymph nodes.
What are the causes of lymphadenopathy?
- M- alignancy
- I - nfection
- A - utoimmune
- M - iscellaneous
- I - atrogenic
What are the causes of Follicular Hyperplasia?
- Rheumatoid arthritis
- Syphilis
- Toxoplasmosis
- HIV infection
- Castleman disease
(giant lymph node hyperplasia)
What are the types of HIV - Associated Lymphadenopathy?
- Explosive Follicular Hyperplasia(Pattern A- Acute)
- Mixed (Pattern B- Chronic)
- Follicular Involution
(Pattern C- Burned-out pattern; Lymphocyte Depletion)
