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Hematology 2 (Lecture) > Megakaryopoiesis (P) > Flashcards

Megakaryopoiesis (P) Flashcards

1
Q

What are the 2 phases (or stages) of megakaryopoiesis?

A

1) Proliferative Phase

2) Terminal Differentiation

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2
Q

What are the type of megakaryocytes under proliferative phase?

A

Megakaryocyte progenitors

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3
Q

How are megakaryocyte progenitors described under proliferative phase?

A

Described based on their characteristics in vitro

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4
Q

What type of cell does all cells under proliferative phase resemble?

A

Lymphocytes

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5
Q

What are the type of megakaryocytes under terminal differentiation?

A

Megakaryocyte precursors

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6
Q

How are megakaryocyte precursors described under terminal differentiation?

A

Described based on their morphology in Wright-stained aspirate and H&E-stained biopsies

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7
Q

What does the first cell stage under terminal differentiation resemble?

A

Myeloblasts or pronormoblasts

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8
Q

Where does Megakaryocyte-Erythrocyte Progenitor arise from?

A

Arise from common myeloid progenitor

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9
Q

What are the 2 (chemical components) of Megakaryocyte-Erythrocyte Progenitor?

A

1) GATA-1

2) MYB

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10
Q

What is the meaning of BFU-Meg?

A

Burst-Forming Unit Meg

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11
Q

What are the characteristics of BFU-Meg?

A

1) Least mature
2) Diploid
3) Normal mitosis
4) 100 cells in vitro

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12
Q

What is the meaning of CFU-Meg?

A

Colony-Forming Unit Meg

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13
Q

What are the characteristics of CFU-Meg?

A

1) Intermediate
2) Diploid
3) Normal mitosis
4) 12 cells in vitro

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14
Q

What is the meaning of LD-CFU-Meg?

A

Light-Density Colony-Forming Unit Meg

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15
Q

What are the characteristics of LD-CFU-Meg?

A

1) More mature
2) Polyploid
3) Endomitosis

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16
Q

What is the (chemical component) present on LD-CFU-Meg?

A

RUNX1

17
Q

What is the meaning of MK-I?

A

Megakaryoblast

18
Q

What are the characteristics of MK-I?

A

1) Least differentiated
2) Plasma membrane blebs
3) Cytoplasmic structure starts to develop

19
Q

What is the meaning of MK-II?

A

Promegakaryocyte

20
Q

What are the characteristics of MK-II?

A

1) Starts with indentation of nucleus

2) Ends if full ploidy is reached

21
Q

What is the meaning of MK-III?

A

Megakaryocyte

22
Q

What are the characteristics of MK-III?

A

1) Easily recognized

2) Ploidy levels can be measured

23
Q

What is used to measure ploidy levels of MK-III?

A

Propidium iodide

24
Q

What is the other term for thrombocytes?

A

Platelets

25
Q

How are platelets formed?

A

Result from shredding of megakaryocytes

26
Q

What are the purposes of thrombopoietin?

A

1) Induces stem cell-megakaryocyte
2) Induces megakaryocyte progenitor-precursor
3) Induces megakaryocyte proliferation and maturation
4) Induces thrombocytopoeisis

27
Q

What is the meaning of TPO?

A

Thrombopoietin

28
Q

What are the therapeutic agents available for TPO and IL-11 (to act as an alternative for these 2 components)?

A

1) For TPO: romiplostim and eltrombopag

2) For IL-11: oprelvekin

29
Q

What is the main function (or principle) of GATA-1?

A

To increase

30
Q

What is the main function (or principle) of MYB?

A

To decrease

Hematology 2 (Lecture) (11 decks)

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