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Hematology 2 (Lecture) > Antithrombotic Therapies (F) > Flashcards

Antithrombotic Therapies (F) Flashcards

1
Q

What is antithrombotic therapy?

A

1) Employed to prevent thrombus formation

2) Utilized to destroy thrombus in vasculature

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2
Q

What are the types of antithrombotic therapy?

A

1) Antiplatelet drugs
2) Anticoagulants
3) Thrombolytics or fibrinolytics

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3
Q

What is the function of antiplatelet drugs?

A

Suppress PLT activation

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4
Q

What are the functions of anticoagulants?

A

1) Suppress coagulation

2) Reduce thrombin formation

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5
Q

What is the function of thrombolytics or fibrinolytics?

A

Disperse or reduce existing clots that clog veins and arteries

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6
Q

What are the antithrombotic drugs administered via the oral route?

A

1) Aspirin
2) Naproxen
3) Ketoprofen
4) Fenoprofen
5) Sulfinpyrazone
6) Ibuprofen
7) Clopidogrel
8) Prasugrel
9) Ticlopidine
10) Ticargrelor
11) Vorapaxar
12) Dabigatgran
13) Rivaroxaban
14) Apixaban
15) Edoxaban
16) Betrixaban
17) Warfarin

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7
Q

Given antithrombotic drug: Aspirin

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs
b. Inhibits eicosanoid pathway by inhibiting cyclooxygenase
2) a. One of the most commonly prescribed antiPLT drugs
b. Effects are irreversible

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8
Q

Given antithrombotic drug: Naproxen

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs
b. Inhibits eicosanoid pathway by inhibiting cyclooxygenase
2) Effects are reversible

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9
Q

Given antithrombotic drug: Ketoprofen

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs
b. Inhibits eicosanoid pathway by inhibiting cyclooxygenase
2) Effects are reversible

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10
Q

Given antithrombotic drug: Fenoprofen

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs
b. Inhibits eicosanoid pathway by inhibiting cyclooxygenase
2) Effects are reversible

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11
Q

Given antithrombotic drug: Sulfinpyrazone

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs
b. Inhibits eicosanoid pathway by inhibiting cyclooxygenase
2) Effects are reversible

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12
Q

Given antithrombotic drug: Ibuprofen

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs
b. Inhibits eicosanoid pathway by inhibiting cyclooxygenase
2) Effects are reversible

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13
Q

Given antithrombotic drug: Clopidogrel

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs
b. Inhibits PLT membrane function by inhibiting P2Y12 receptor or ADP receptor
2) a. One of the most commonly prescribed antiPLT drugs
b. Effects are irreversible

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14
Q

Given antithrombotic drug: Prasugrel

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs
b. Inhibits PLT membrane function by inhibiting P2Y12 receptor or ADP receptor
2) a. One of the most commonly prescribed antiPLT drugs
b. Effects are irreversible

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15
Q

Given antithrombotic drug: Ticlopidine

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs

b. Inhibits PLT membrane function by inhibiting P2Y12 receptor or ADP receptor

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16
Q

Given antithrombotic drug: Ticargrelor

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs
b. Inhibits PLT membrane function by inhibiting P2Y12 receptor or ADP receptor
2) a. One of the most commonly prescribed antiPLT drugs
b. Effects are reversible

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17
Q

Given antithrombotic drug: Vorapaxar

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs

b. Inhibits PLT membrane function by inhibiting protease-activated receptor-1

18
Q

Given antithrombotic drug: Dabigatgran

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> anticoagulant

b. Inhibits coagulation cascade through direct inhibition of factor IIa

19
Q

Given antithrombotic drug: Rivaroxaban

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> anticoagulant

b. Inhibits coagulation cascade through direct inhibition of factor Xa

20
Q

Given antithrombotic drug: Apixaban

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> anticoagulant

b. Inhibits coagulation cascade through direct inhibition of factor Xa

21
Q

Given antithrombotic drug: Edoxaban

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> anticoagulant

b. Inhibits coagulation cascade through direct inhibition of factor Xa

22
Q

Given antithrombotic drug: Betrixaban

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> anticoagulant

b. Inhibits coagulation cascade through direct inhibition of factor Xa

23
Q

What are the antithrombotic drugs that are administered via intravenous line?

A

1) Cangrelor
2) Abciximab
3) Eptifibatide
4) Tirofiban hydrochloride
5) Dypyridamole
6) Argatroban
7) Bivalirudin
8) Heparin
9) Reteplase
10) Alteplase
11) Tenecteplase
12) Purified urokinase
13) Steptokinase

24
Q

Given antithrombotic drug: Cangrelor

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs
b. Inhibits PLT membrane function by inhibiting P2Y12 receptor or ADP receptor
2) Effects are reversible

25
Q

Given antithrombotic drug: Abciximab

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs

b. Inhibits PLT membrane function by inhibiting GP IIb/IIIa receptor

26
Q

Given antithrombotic drug: Eptifibatide

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs

b. Inhibits PLT membrane function by inhibiting GP IIb/IIIa receptor

27
Q

Given antithrombotic drug: Tirofiban hydrochloride

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs

b. Inhibits PLT membrane function by inhibiting GP IIb/IIIa receptor

28
Q

Given antithrombotic drug: Dypyridamole

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> antiPLT drugs

b. Inhibits PLT membrane function by inhibiting phosphodiesterase

29
Q

Given antithrombotic drug: Argatroban

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> anticoagulant

b. Inhibits coagulation cascade through direct inhibition of factor IIa

30
Q

Given antithrombotic drug: Bivalirudin

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> anticoagulant

b. Inhibits coagulation cascade through direct inhibition of factor IIa

31
Q

Given antithrombotic drug: Warfarin

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> anticoagulant
b. Inhibits coagulation cascade by being a vitamin K antagonist
2) a. Affects vitamin K dependent proteins - factors X, IX, VII, II, protein C, protein S, and protein Z

32
Q

Given antithrombotic drug: Heparin

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> anticoagulant
b. Inhibits coagulation cascade through indirect inhibition of factor IIa and Xa
2) a. Also called unfractionated heparin or standard heparin
b. Antithrombin is needed for the rxn to take place

33
Q

Given antithrombotic drug: Reteplase

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> thrombolytics
b. Initiates fibrinolysis by activating plasmin
2) a. Acts as a tissue plasminogen activator

34
Q

Given antithrombotic drug: Alteplase

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> thrombolytics
b. Initiates fibrinolysis by activating plasmin
2) Acts as a tissue plasminogen activator

35
Q

Given antithrombotic drug: Tenecteplase

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> thrombolytics
b. Initiates fibrinolysis by activating plasmin
2) a. Acts as a tissue plasminogen activator

36
Q

Given antithrombotic drug: Purified urokinase

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> thrombolytics
b. Initiates fibrinolysis by activating plasmin
2) a. Acts as a urokinase plasminogen activator

37
Q

Given antithrombotic drug: Streptokinase

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> thrombolytics
b. Initiates fibrinolysis by activating plasmin
2) a. Cleaves arginine and valine to activate plasmin

38
Q

What are the antithrombotic drugs that are administered via subcutaneous injection?

A

1) Fondaparinux sodium
2) Enoxaparin
3) Tinzaparin
4) Dalteparin

39
Q

Given antithrombotic drug: Fondaparinux sodium

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> anticoagulant
b. Inhibits coagulation cascade through indirect inhibition of factor Xa
2) a. Antithrombin is needed for the rxn to take place

40
Q

Given antithrombotic drug: Enoxaparin

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> anticoagulant
b. Inhibits coagulation cascade through direct inhibition of factor Xa
2) a. Considered as a low molecular wt heparini

41
Q

Given antithrombotic drug: Tinzaparin

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> anticoagulant
b. Inhibits coagulation cascade through direct inhibition of factor Xa
2) a. Considered as low molecular wt heparin

42
Q

Given antithrombotic drug: Dalteparin

Answer the ff questions:

1) What are the effects?
2) What are the characteristics?

A

1) a. General -> anticoagulant
b. Inhibits coagulation cascade through direct inhibition of factor Xa
2) a. Considered as a low molecular wt heparin

Hematology 2 (Lecture) (11 decks)

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