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Medulloblastoma, WNT-activated (WHO grade 4) > Medulloblastoma, WNT-activated (WHO grade 4) > Flashcards

Medulloblastoma, WNT-activated (WHO grade 4) Flashcards

1
Q

Medulloblastoma, WNT-activated age

A

Older child , rarely adult

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2
Q

Histology type Medulloblastoma, WNT-activated g4

A

Classic
Rarely Large cell/anaplastic morphology.

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3
Q

Medulloblastoma, WNT-activated (WHO grade 4) 📍

A

cerebellar midline
Around foramen of Luschka, arising from the brainstem or cerebellum

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4
Q

Medulloblastoma, WNT-activated (WHO grade 4) origin

A

lower rhombic lip progenitor cells

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5
Q

Medulloblastoma, WNT-activated (WHO grade 4) genetic mutation

A

CTNNB1, DDX3X, TP53.

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6
Q

Prognosis

A

Children excellent
Adult poor

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7
Q

Dx

A
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Medulloblastoma, WNT-activated (WHO grade 4) (4 decks)

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