Medulloblastoma, SHH-activated, TP53-wildtype (WHO grade 4)

Question 1

Medulloblastoma, SHH-activated, TP53-wildtype (WHO grade 4) age

Answer 1

Bimodal age infancy and adult

Question 2

Medulloblastoma, SHH-activated, TP53-wildtype (WHO grade 4) MCC histology

Answer 2

desmoplastic/nodular.▶️ low risk
Others ;
Classic ▶️ stander risk

Extensive nodularity morphology (MBEN).▶️ low risk

Question 3

Medulloblastoma, SHH-activated, TP53-wildtype origin

Answer 3

cerebellar granule neuron cell precursors ▶️▶️ of the external granule cell layer and cochlear nucleus

Question 4

Medulloblastoma, SHH-activated, TP53-wildtype genetic

Answer 4

PTCH1, SMO (adults), SUFU (infants), TERT promoter.

Question 5

Medulloblastoma, SHH-activated, TP53-wildtype 📍

Answer 5

cerebellar vermis

children and young adults: mainly involves the hemispheres.