Medulloblastoma, non-WNT/non-SHH (WHO grade 4)

Question 1

Medulloblastoma, non-WNT/non-SHH (WHO grade 4) sup type

Answer 1

Group 3
Group 4

Question 2

Medulloblastoma, non-WNT/non-SHH (WHO grade 4) MCC age

Answer 2

Infancy and childhood

Question 3

Medulloblastoma, non-WNT/non-SHH (WHO grade 4) MCC histology

Answer 3

Classic ▶️ stander risk
Large cell/ anaplastic ▶️ group 3 > group 4 , , high risk 🔴

Question 4

Medulloblastoma, non-WNT/non-SHH (WHO grade 4) 📍

Answer 4

inferior cerebellum, usually near the midline

Question 5

Medulloblastoma, non-WNT/non-SHH (WHO grade 4
Origin

Answer 5

cerebellar granule neuron cell precursors of the external granule cell layer

Question 6

Medulloblastoma, non-WNT/non-SHH (WHO grade 4) genetic

Answer 6

PVT1-MYC, GFI1/GFI1B structural variants.

Question 7

Medulloblastoma, non-WNT/non-SHH subtype

Answer 7

8 molecular ▶️▶️ differentiated by DNA methylation profiling.

Question 8

Medulloblastoma, non-WNT/non-SHH prognosis

Answer 8

Group 3 ➡️ MYC amplification➡️ poor prognosis
Group 4 Mets strongest poor prognosis , ➕ chrom 7,17 , ➖ 8 , 11