Meds- OB Flashcards
Ampicillin
Indication
Dose
MOA
SI/CI
2g then 1g q4h IV
GBS ppx- inhibits cell wall synthesis
Allergy
Rhogam
Indication
Dose
MOA
Side effects/CI
Rh neg
300 mcg IM
clears anti-D coated red cells
allergy
Betamethasone
Indication
Dose
MOA
Side effects/CI
antenatal steroids
12mg IM q24h x 2 doses
accelerates pneumocyte development
Allergy
Magnesium sulfate neuroprotection
Indication
Dose
MOA
Side effects/CI
6g bolus, then 2g IV/hr
stabilizes cerebral blood flow, reduces CP
Flushing, NV
Magnesium seizure ppx/ eclampsia
Indication
Indication
Dose
MOA
Side effects/CI
4g bolus then 2g/hr IV
4-6g bolus for eclampsia
increases seizure threshold, vasodilation
toxicity, renal disease
PPROM latency abx
Indication
Dose
MOA
Side effects/CI
ampicillin 2g q6h x 48h IV, then amox 250 mg q8h x5d PO
azithromycin 1g po x1
GBS, gram neg, anerobes, CT/ureaplasma
allergy
labetalol
Indication
Dose
MOA
Side effects/CI
antihypertensive
20, 40 80 mg IV q10h
beta blocker
asthma, bradycardia
max dose IV is 300 mg
Nifedipine
Indication
Dose
MOA
Side effects/CI
10-20 mg PO q20 min
antihypertensive
calcium channel blocker
tachycardia,headache
max daily dose is 180 mg
hydralazine
Indication
Dose
MOA
Side effects/CI
anti hypertensive
5, 10 mg IV q 20 min
max daily dose is 20 mg IV
arterial vasodilator
headache
aspirin
Indication
Dose
MOA
Side effects/CI
preeclampsia prevention
81 mg PO
decreases thromboxane production (thromboxane promotes vasoconstriction and platelet aggregation)
allergy, high risk for bronchospasm (nasal polyps or asthma), hx of GI bleeding or PUD
ursodeoxycholic acid
Indication
Dose
MOA
Side effects/CI
cholestasis
300 mg PO TID
decreases cholesterol content of bile
allergy
oxytocin
Indication
Dose
MOA
Side effects/CI
IOL , uterotonics
2mu/min IV
activates receptors to stimulate contractions (elevated intracellular calcium)
Hypotension/Na, tachysystole
for PPH
40 u in 1L, increases uterine contractility, hypotension, CV collapse
misoprostol
Indication
Dose
MOA
Side effects/CI
IOL, uterotonic
25 mcg q3-6h PV
PGE1 analogue
tachysystole, not for VBAC
for PPH- 1000 mcg PR/SL, hyperthermia
Levothyroxine
Indication
Dose
MOA
Side effects/CI
thyroid replacement
1mg/kg/day PO
synthetic levothyroxine
due to overtreatment
PTU
Indication
Dose
MOA
Side effects/CI
hyperthyroid
100 mg PO TID
blocks thyroid hormone synthesis (interferes with TPO)
hepatotoxicity
Hemabate
Indication
Dose
MOA
Side effects/CI
uterotonic
0.25 mg IM q15 min for max of 8 doses
PGF2 a analogue
asthma
Methergine
Indication
Dose
MOA
Side effects/CI
uterotonic
0.2 mg IM q2h
increases smooth muscle contractions/tone
HTN,CAD, raynauds
Tranexamic acid
Indication
Dose
MOA
Side effects/CI
hemorrhage
1g IV over 10 min
inhibits fibrinolysis and plasmin activity
headaches
Ancef
Indication
Dose
MOA
Side effects/CI
antibiotic ppx, PPH
2g
broad spectrum
allergy
micronized progesterone
Indication
Dose
MOA
Side effects/CI
short cervix
200 mg PV qhs
maintains uterine quiescents; prevents fetal membrane apoptosis
abnormal discharge
lidocaine
Indication
Dose
MOA
Side effects/CI
local anesthesia
60 cc 0.5 with epi (30 cc without) max
7 cc/kg with epi, 4 cc/kg without
blocks Na channels and nerve conduction
Seizure, MI, allergy
amp/gent (clinda)
chorio
amp: 2g q6h - gram positive
gent: 5 mg/kg q24h - gram negatives
clinda: 900 mg q8h - mrsa and anaerobes
broad spectrum allergy
ancef for retained placenta
2g x1 dose
heparin MOA
potentiates ATIII to inactive thrombin (as well as other coag factors like Xa)
prevents conversion of fibrinogen to fibrin
insulin
Indication
Dose
MOA
Side effects/CI
diabetes
0.7-1 u/kg/day total.
regulates metabolism of carbohydrates, synthesizes glycogen
hypoglycemia
Metformin
Indication
Dose
MOA
Side effects/CI
diabetes
500 mg PO daily to BID
decreases hepatic glucose production and intestinal absorption
lactic acidosis
Glyburide
Indication
Dose
MOA
Side effects/CI
2.5 mg PO daily
stimulates insulin release from beta cells
hypoglycemia
diabetes in labor
1u/hr if FS >120
in D5 1/2 NS
regular insulin
doxylamine-pyridoxine
Indication
Dose
MOA
Side effects/CI
nausea and vomiting in pregnancy
10mg/10 mg; 2 tabs qhs, max 4/day
antihistamine, gaba activity
fatigue, dizziness, palpitations
Nifedipine tocolysis
10-30 mg loading
20 mg every 6 hours for 48 hours
Max dose is 180
Indomethacin tocolysis dose
50-100 mg loading
25 mg every 6 hours for 48 hours
Max dose is 200 mg daily
Pcn GBS PPx
Ancef GBS PPx
5 million units for loading dose
2.5 million for maintenance q4h
2g initial and 1 g q8 h
