Medicines Design - Eggleston Flashcards
What is the peptide and protein therapeutics “SWOT” analysis?
S = Strengths
W = Weaknesses
O = Opportunities
T = Threats
Which type of HPLC is best for peptides?
Reverse phase HPLC
How many AA are in each of the peptide chains in insulin?
Chain A = 21
Chain B = 30
When would peptide mapping be done?
To see the difference between large peptides when there is only a 1/2 AA difference
How does DPP4 inhibit GLP-1?
Cleaves off dipeptide units Xaa-Ala or Xaa-Pro
What is Liraglutide?
97% similar to GLP-1 –> so less immunogenicity than exenatide
Once daily doing (compared to exenatides 2)
What type of protease is DDP4?
Serine Protease
Why are non-covalent DDP-4 inhibitors better than regular ones?
As they have greater selectivity for DDP-4 –> When compaered to those than covalently bind
What are SGLT2 molecules based off of?
Phlorizin
