Medicines Design - Blag

Question 1

What is Exenatide?

Answer 1

A GLP-1 agonist

Injected SC

Side effects are of benefit to the patient!!

• Blocks pancereatic B cell apoptosis, and stimulates synthesis
• Promtotes satiety –> So can help people lose weight

Question 2

What is the difference between a ‘Clean Drug’ and a ‘Dirty Drug’?

Answer 2

Clean –> Binds to one target site

Dirty –> Binds to several sites

So has many side effects…..which can be useful occasionally!!

Question 3

Who shouldn’t take Aspirin?

Answer 3

Those who are prone to stomach ulcers

Those on other NSAIDs (as promotes the above)

Question 4

How did is Vitamin D formed?

Answer 4

Cholesterol is dehydrogeneated (oxidised) with skin P450s –> adding a double bond between carbons 7 and 8

Question 5

What is Vitamin D used for?

Answer 5

Osteoporosis –> Mainly in post-menopausal women

Question 6

What is an example of a 19-no-steroid?

Answer 6

Estradiol

There has been a loss of a methyl at carbon 19, allowing the A ring to be aromatic (planar)

Question 7

What do the dash and wedge represent? In terms of the face of the molecule

Answer 7

Wedge = Top phase (B)

Dash = Bottom phase (a)

Question 8

How do we know if steroids are AB/CD Cis/Trans?

Answer 8

Cis –> If the molecules at 5 and 10 (or 13 and 14) are on the same face (eg, B)

Trans –> If the molecules are on opposite sides (one A one B)