Medicine 4 Flashcards
11moF comes to ED with parents. Has had fever to 102 for several days and now decreased PO, bilateral conjucntival erythema with watery discharge and erythematous rash that started on the cheeks, now spread to rest of the body
Exam: macolopapular rash on face, trunk and proximal extremities sparing palms and soles. mulitple anterior cervical LN. Several kids at daycare w/ sim illness
Rubeola or Measles; vaccine preventable.
Cough, corzya and conjuctivitis; maculopapular rash starts on face–> cephalocaudal spread
Can get Koplik spots on buccal mucosa
2 yo presents with fever and cough for several days, then developed red rash on cheeks and reticular truncal rash
Parvovirus
Rough small erythematous lesions on sun exposed areas. Seen in old people
Dx
Tx
risk if left untreated
Actinic keratosis
5 fluorouracil, cryotherapy, excision
Squamous cell carcinoma
tx epidural block or decompression
Low back pain that is WORSE with extension, prolongued standing and better when sitting or bending forward. Seen in old people
lumbar spinal stenosis
Get MRI for diagnosis
Hypopigmented lesions scattered on body, family hx of bilateral deafness
NF-2
Facial port wine stain and leptomeningeal angiomatosis
Sturge Weber
Congenital hypopigmented maclues (ash leaf), glial proliferation, several organ hamartomas/cysts
Tuberous sclerosis
Pt with cutaneous neurofibromas, unilateral acoustic neuroma, axllary freckles
NF-1
Pt with HIV can have transient worsening of symptoms several weeks after initiation of ART due to _____
immune reconstitution inflammatory syndrome
From potent immune recovery that quickly occurs after initiation of ART; self limited and requires NO alteration to current therapy
PT comes in with pain and deformity of the wrist. The xray shows fracture of the distal radius.
MCC of this fracture?
Colles fx
FOOSH; fall onto outstretched hand; may have concurrent ulnar styloid fracture
Are at increased risk for carpal tunnel syndrome
manage with splint unless >15 to 20 degree angulation then likely reduction
Mom is pregant, on US they notice dilated kidneys, mild thickening of the bladder wall. Later diagnosed with oligohydramnios. Most likely cause?
Posterior urethral valves
Dx with voiding cystourethrogram
Pain in anterior knee, worse with climbing or squatting, running, prolonged sitting, has been going on for a few months.
Normal knee exam xray with pain on extension of knee with anterior patellar compression
Patellofemoral pain syndrome
Gardener comes in with significant left knee pain. Swelling noted around the anterior knee and localized swelling.
Prepatellar bursitis
often complicated by secondary infection; S.Aureus
Women 6 weeks post partum comes in with wt loss, sweating, fatigue and heat intolerance. She has already lost 15 pounds, no menstration. She is tachy to 110, has enlarged and nontender thyroid on exam, no nodules.
TSH <0.01, T4 is elevated and elevated anti-thyroid peroxidase antiB.
Radioactive iodine in thyroid gland is very low.
Dx?
Postpartum thyroiditis
Pt has primary hyperthyroidism (low TSH, elvated T4), can tell apart from Hashimoto by RAIU which would be HIGH
Drugs associated with pancreatitis
Tylenol/NSAIDS/Mesalamine
Sulfa containing drugs
ABx: isoniazid, tetracyclines, metronidazole, bactrim
AED: Valproic adn carbamazepine
Diuretics: thiazide, furosemide or enalapril/losartan
immunosuppresants: azathioprine, mecercaptopurine, steroids
___ should be stopped on day contrast is given with cardiac cath especially those with renal insufficiency, hepatic dysnfnx or EtOH abuse or CHF due to increased risk for lactic acidosis when combined with large dose IV contrast.
Metformin
7yo presents with leg weakness/tired after soccer practice, otherwise no complaints. On PE you hear a cont systolic murmur on the back in the left interscapular area, has elevated BP in RUE. Vitals and PE otherwise NML.
Dx
Coarctation of aorta
you can see rib knotching on CXR with figure “3” sign of aortic narrowing and have hypotension of LE with delayed pulses
Echo to confirm dx
Pulses paradoxus or decline in BP (>10mmg HG) during inspiration occurs in which pathology?
tamponade
pt with chest pain, dyspnea, hypoT, JVD, muffled heart sounds
Pt has elevated calcium, elevated parathyroid levels, and lipomas on back with hx of GI bleed.
Suspicious for?
MEN1: 3 Ps: parathyroid adenoma/hyperplasia, pancreatic or GI tumor (zolliger ellison) and Pituitary adenoma; associated with lipomas
Need parathyoidectomy if dx <50yo
Primary hyperparthyroidism, Medullary thyroid carcinoma and pheochromocytoma are seen in?
MEN 2A
–test for calcitonin (MTC) and metanephrines
MEdullary thyroid cancer, pheo and mucosal neuromas/marfinoid
MEN2B
Pt with jaundice, nausea comes to office. Unclear vaccination hx, multiple sexual partners. Hep B surface antiB: Neg Hep B core antiB IgM + Hep B core antiB IgG: Neg Hep B ssurface antigen: + Hep C antiB: Neg HIV: Neg Elevated AST and ALT Dx? Tx?
Acute Hep B
monitor labs closely; acute liver failure VERY rare and most cases resolve spontaneously
Hospitalize if abnormal coags, septic or HD unstable or >50 yo
What patients with newly dx Hep B get antiviral therapy/
immunosuppressed pts, concurrent hep C, severe hepatitis, fulminant hepatic failure
Who recieves Hep B vaccine and immunoglobulin
those exposed to known hep B pt or needle stick
When are you dx with chronic hep B?
If you still have not cleared Hep B surfance antigen w/i 6 months of infection
What type of arrythmia do pt with hyperthyroidism present with? What do we do for them?
can have supraventricular arrythmias (like a fib) thus should be treated with B blockers to control heart rate while started on tx for their hyperthyroidism which can take weeks
Pt with unilateral facial weakness, can’t raise eyebrow with drooping of corner of mouth and disappearance of nasolabial fold
Dx
Tx
Bells palsy; idiopathy CN VII neuropathy INVOLVES the eyebrow.
Tx is steroids (even if HSV is implicated)
When diverticulitis does not improve with oral outpatient therapy in 2-3 days,what is the next step
repeat CT to eval for complications
Goal TSH level while on levothyroxine for small, low risk tumors (papillary)?
Goal dose levothyroxine for target TSH 0.1 to 0.5 for about a year then low normal range (<2.0)
How do you handle shoulder dystocia?
Breathe, don’t push, elevate the legs and flex the hips with thighs to abdomen (McRoberts), apply suprapubic pressure as next step, episostomy next step and then deliver posterior arm
First line treatment for tinea capitis?
ORAL griseofulvin, oral terbinafine also acceptable
Necrotizing fasciitis; pain out of proportion, swelling, ertyhema as well as fever and hypotension.
Two common causes?
Type I; from trauma or surgery; GAS or strep pyogenes
Type II: underlying diabetes or peripheral vascular disease and polymicrobia (Staph, bacteriodes, E.coli)
Crepitus = Clostridium perfringes
–Pip/Tazo or cabapenem +
–Vanc +
–Clinda
Common side effect of calcium channel blockers (amlodipine
peripheral edema
less SE when combined with ACE inhibitors
Pt present with dementia/forgetfulness over the past year and gat instability. Neuro exam notable for spastic paresis and hyperreflexia
Vit B12 deficiency; Subacute combined degeneration with lateral corticospinal tract abnormalities
Pt with known T1DM presents with HA, purulent nasal discharge, fever, facial pain and swelling, nasal eschar present with nasal turbinate necrosis.
Concern for?
Tx?
rhino-orbital cerebral mucormycosis; seen with diabetes and associated with ketoacidosis
Tx: liposomal amphotericin B and debridement as well as sinus endoscopy
Three positive tests for carpal tunnel syndrome
Phalen (hyperflexion of wrists) Tinel sign (taping over the Median nerve), hand elevation over head all makes symptoms worse
Tx: first line is nightime splinting; steroids don’t work great; just temporary relief. and last resort is surgery but get nerve conduction study first to assess severity and alt diagnosis
Pt is 70 yo having months of morning joint stiffness in hips, shoulders and neck. Has lost about 5 pounds, no headaches, no other complaints. Stiffness gets better throughout the day
PE notable for decreased ROM in shoulders and hips
ESR of 50, CRP of 3, normocytic anemia
Likely Dx?
Tx?
Polymyalgia rheumatica
LOW dose steroids; most respond w/in 3-5 days
–failure to improve leads to alternative dx
What disease is polymyalgia rheumatica associated with?
Giant cell arteritis
suspect in pt with higher fevers and tenderness over temporal artery, should consider temporal artery Bx if suspect and needs high dose steroids
Risk of ____ is increased following renal transplant when on steroids especially in the first few months likely 2/2 to both steroids and calcineurin inhibitors
Diabetes mellitus; increased insulin and gluconeogenesis by new kidneys.
Pt with increased wt gain in abdomen with striae, buffalo hump and thin extremities and round face/pleathoric.
Urinary cortisol level is 3 times normal, high dose dexamethasone does not suppress cortisol and plasma ACTH levels are undetectable.
Next best step?
Get CT of adrenal glands
Pt with symptoms of MI comes to ED. EKG shows elevated ST in II, III and aVF which is indicitative of MI in _____
What other features do they present with?
How do we treat?
What meds should be avoided
II, III, avF = inferior MI; likely Right ventricle.
Hypotension, shock or JVD with lear lung fields.
Tx dual antiplatelet, statins, anticoag and may need emergent revascularization
DO NOT give nitrates, diuretics or opiods; all decrease ventricular preload–> lead to hypotension
BOLUS them; they need preload
if they have bradycardia; may need atropine or pacing if arrhythmia
SLE increases risk of what type of CV disease
increases development of premature coronary atheroscloerosis and CAD.
Can cause pericarditis, too but more commonly see friction rub on auscultation and dyspnea
SLE pt increased risk for this type of cancer. See rapidly enlarging mass in neck or abdomen, get vascular or airway compression
Non-hodgkin lymphoma; diffuse large B cell lymphoma
What anti-HTN drugs are considered safe to use with lithium?
Ca channel blockers; amlodipine or verapamil
or loop diuretics
Pt with T score of
Osteoporosis bisphosphonates (alendornate)
Pt with T score of -1 to -2.5 have ___
What are next steps?
Osteopenia
Calculate 10 year fracture risk with FRAX; get labs; serum chem, CBC, 25-hydroxyvitamin D
Lifestyle; avoid smoking, excessive EtOH, wt bearing exercise, increase Ca and Vit
Delayed puberty in boys is defined by lack of testicular enlargement by age ____.
Wht is the initial evaluation
Age 14
Get bone age radiograph, measure FSH, LH, testosterone levels
Lights criteria:
Pleural protein/serum protein >0.5 OR
Pleural LDH/serum LDH >0.6 OR
Pleural LDH >2/3 upper limit normal serum LDH
TRANSudative effusion from inflammation
infection, malignancy, CT diesease, PE, pancreatitis, post-CABG
Exudative pleural effusion causes
hydrostatic or oncotic pressure
cirrhosis, nephrotic syndrome, heart fail, constrictive pericarditis