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Exam 1 FTM > Medications > Flashcards

Medications Flashcards

1
Q

Actinomycin D

A

Anti cancer

Intercalated between G-C bases

Inhibits DNA replication and transcription
(RNA synthesis)

(Has “IN” in word)

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2
Q

Acyclovir

A

Phosphorylation by viral thymidine kinase

Inhibits viral polymerase (viral replication)

Herpes/varicella zoster

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3
Q

Alpha-amanitin toxin (phalloides)

A

Toxin

Inhibitor of RNA polymerase II
(Eukaryotes)

No mRNA formed

Treatment:

  • GI decontamination
  • penicillin
  • liver transplant
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4
Q

Azidothymine (AZT) zidovudine

A

Viral reverse transcriptase

Inhibitor of viral replication

Treats:
-HIV

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5
Q

Caffeine

A

Inhibits phophodiaterase

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6
Q

Camptothecin

A

Anti cancer
Inhibits topoisomerase I (eukaryotes)

(One O)

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7
Q

Chloramphenicol

A

Antibiotic

Prevents elongation
Inhibits peptidyltransferase (prokaryotes)
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8
Q

Ciprofloxacin/Nalidixic acid

A

Inhibits bacteria DNA gyrase (topoisomerase II) = positive supercoiling

Disrupts DNA replication and transcription

Treats:

  • respiratory infections
  • UTI
  • Anthrax
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9
Q

Cycloheximide

A

Antibiotic

Prevents elongation of translation

Inhibits eukaryotic peptidyltransferase

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10
Q

Diphtheria

A

Toxin

Inactivated eukaryotic EF-2

Prevents translocation

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11
Q

Tetracycline

A

Antibiotic

Blocks access to A site
Preventing elongation if translation (prokaryotes)

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12
Q

Tenofovir

A

Competes w deoxy-ATP For incorporation

Viral reverse transcriptase
Inhibits of viral replication

Treats:
-HIV

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13
Q

Streptomycin

A

Distorts initiation of translation (prokaryotes)

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14
Q

Rifamycin

A

Blocks first phosodiester bond by binding PROKARYOTE RNA POLYMERASE

Inhibiting initiation of transcription

Treats:
TB

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15
Q

Puromycin

A

Antibiotic

Blocks elongation
Premature translation termination (PROKARYOTES AND EUKARYOTES)

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16
Q

Erythromycin

A

Blocks translocation
Preventing elongation
(PROKARYOTES)

17
Q

Etoposide

A

Anti cancer

Inhibits topoisomerase II
EUKARYOTES

18
Q

Novobiocin

A

Antibiotic

Inhibits DNA gyrase
(PROKARYOTES)

Treats:
-staph infection

19
Q

Allopurinol

A

Inhibits xanthine oxidase

Treatment:
-gout

20
Q

5-fluorouracil

A

Anti cancer

Inhibits thymidylate kinase = synthesis of thymine

21
Q

Theophylline

A

Inhibits phosphodiesterase

22
Q

Cystosine arabinoside (cytarabine)

A

Inhibits human DNA polymerase from steric strain

Inhibits DBA replication

Treatment:
-leukemia

23
Q

Adenosine arabinoside (vidarabine)

A

Inhibits viral DNA polymerase

Treats
-leukemia

24
Q

5-aka-2’-deoxycytidine (decitabine)-5-azacytidine

A

More transcription

DNA methyl-transferase (methyl group cannot be added to nitrogen)

25
Q

Azathiprine

A

Inhibits an enzyme

Required for DNA synthesis

Suppresses rejection during organ transplantation

26
Q

Didanosine

A

Viral reverse transcriptase

Inhibitor of viral replication

Treats:
-HIV

Exam 1 FTM (22 decks)

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