Glucose Transport

Question 1

Glut 1

Answer 1

RBC (Erythrocytes), Kidneys, blood brain barrier

high affinity

Rate remains constant no matter glucose [ ]

Disease:

• Hereditary Glut-1 Deficiency
• Metabolic encephaly (epilepsy)

Question 2

Glut 2

Answer 2

Pancreatic B-cells, Hepatocytes, Intestinal mucosal cells, renal tubules cells

low affinity

Question 3

Glut 3

Answer 3

Neurons and brain

high affinity

Rate remains constant no matter glucose [ ]

Question 4

Glut 4

Answer 4

• Insulin dependent
• High Affinity
• skeletal muscles, heart, adipose tissues

Skeletal muscles mobilization by vigorous exerise

Question 5

Glut 5

Answer 5

-Inestinal mucosal cells, seminal vesicles (semen)

Fructose

Question 6

Na+/Atpase

Answer 6

-Primary Active transporter (Requires ATP, low–>high concentration)

Question 7

SGLT

Types

Answer 7

• Secondary active transporter:
• Coupled to Na+ Na/ATPase
• Transports Na+ and specific molecules into the cell

1) SGLT-1: Transports Na+/glucose or Na+/GALACTOSE into mucosal cells (epithelial)
2) SGLT-2: Kidney Transports Na+/glucose for reuptake (Inhibitor used for diabetes

Question 8

CFTR

Answer 8

Cystic Fibrosis Transmembrane Regulator

• Passive transport (flows w gradient, few ATP used)
• Special ABC transporter
• Present in specific epithelial cells, cl- flows out into ducts
  1) Airway ducts
  2) Pancreatic ducts
  3) Reproductive ducts