Medications Flashcards
1st line management for Alzheimer’s disease
Acetylcholinesterase inhibitors
name 3 Acetylcholinesterase inhibitors (AchE-I)
Donepezil
Galantamine
Rivastigmine
medication that is both a butyrylcholinesterase + Acetylcholinesterase inhibitors
Rivastigmine
2nd line management for Alzheimer’s disease
Memantine
mechanism of Memantine
NDMA receptor antagonist
management of vascular dementia (3)
- vascular risk prevention
- statins
- aspirin
Management of Lewy Body Dementia
Rivastigmine
management of Frontotemporal dementia
No pharmacological agents available
side effects of AchE-I
due to increased cholinergic activity
- nausea, vomiting, diarrhoea
- insomnia
- dizziness
- urinary incontinence
indication for Memantine
- monotherapy for people with moderate AD that are intolerant to AchE-I
- severe AD
- taken in combo with AchE-I in those with moderate or severe disease
safest choice of AchE-I for those with CVD?
rivastigmine
side effects of AchE-I + NMDA receptor antagonists
- diarrhoea
- dizziness
- anorexia/weight loss
- n+v
- insomnia
common side effects of Sertraline (6)
- dry mouth
- reduced sex drive
- impotence
- difficulties orgasming
- drowsiness
- GI upset - mild nausea
group of antidepressants with greatest risk of overdose
TCAs
group of antidepressants that are irreversible
MAOI