Medications Flashcards

1
Q

1st line management for Alzheimer’s disease

A

Acetylcholinesterase inhibitors

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2
Q

name 3 Acetylcholinesterase inhibitors (AchE-I)

A

Donepezil
Galantamine
Rivastigmine

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3
Q

medication that is both a butyrylcholinesterase + Acetylcholinesterase inhibitors

A

Rivastigmine

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4
Q

2nd line management for Alzheimer’s disease

A

Memantine

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5
Q

mechanism of Memantine

A

NDMA receptor antagonist

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6
Q

management of vascular dementia (3)

A
  • vascular risk prevention
  • statins
  • aspirin
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7
Q

Management of Lewy Body Dementia

A

Rivastigmine

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8
Q

management of Frontotemporal dementia

A

No pharmacological agents available

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9
Q

side effects of AchE-I

A

due to increased cholinergic activity

  • nausea, vomiting, diarrhoea
  • insomnia
  • dizziness
  • urinary incontinence
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10
Q

indication for Memantine

A
  • monotherapy for people with moderate AD that are intolerant to AchE-I
  • severe AD
  • taken in combo with AchE-I in those with moderate or severe disease
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11
Q

safest choice of AchE-I for those with CVD?

A

rivastigmine

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12
Q

side effects of AchE-I + NMDA receptor antagonists

A
  • diarrhoea
  • dizziness
  • anorexia/weight loss
  • n+v
  • insomnia
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13
Q

common side effects of Sertraline (6)

A
  • dry mouth
  • reduced sex drive
  • impotence
  • difficulties orgasming
  • drowsiness
  • GI upset - mild nausea
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14
Q

group of antidepressants with greatest risk of overdose

A

TCAs

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15
Q

group of antidepressants that are irreversible

A

MAOI

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16
Q

monitoring required for patients on antidepressants

A

2 to 4 weekly in first 3 months… then at longer intervals if the response is good

17
Q

when is monitoring at 1 week following commencing antidepressants required

A

high risk of suicide
or
< 30 years old

18
Q

when should patients remain on antidepressants potentially lifelong

A

> 5 episodes of depression
or
2 episodes in last few years

19
Q

which antidepressant is best in IHD/post MI

A
  • sertraline
20
Q

antidepressants that have an increased risk of GI bleedingq

A

SSRIs

21
Q

important drug counselling for taking an SSRI

A

increased anxiety and agitation after starting

22
Q

2 SSRIs associated with dose dependant QTc interval prolongation

A
  • Citalopram

- Escitalopram

23
Q

common SE of TCAs

A
  • drowsiness
  • dry mouth
  • blurred vision
  • constipation + urinary retention
24
Q

2 examples of SNRI and what is the mechanism of action

A
  • Duloxetine
  • Venlafaxine

inhibits the reuptake of noradrenaline + serotonin at the synaptic cleft leading to increased concentrations of these neurotransmitters