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Gnemoics > Medical Oncology - CRC and lung cancer > Flashcards

Medical Oncology - CRC and lung cancer Flashcards

1
Q

Drugs for colorectal cancer (CRC)

A

5-Floruracil
Capecitabine
Irinotecan
Cetuximab
Panitumumab
Pembrolizumab
Nivolumab

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2
Q

CRC- 5- fluorouracil utility/mutations

A

DPD *2A - splicing mutation

DPD is needed for pyrimidine catabolism

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3
Q

CRC - 5 fluorouracil IM and PM

A

IM: reduce dose by 50%

PM: don’t use

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4
Q

CRC - capecitabine utility/mutation

A

DPD

DPD needed for pyrimidine catabolims

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5
Q

CRC - irinotecan utility/mutation

A

UGT1A16/28 allele

causes reduced enzyme activity and toxicity

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6
Q

CRC - cetuximab utility/ mutations

A

KRAS/NRAS/EGFR

  • focus on exons 2, 3, 4

mutations in KRAS = unchecked growth

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7
Q

CRC - panitumumab utility and mutaion

A

KRAS/NRAS/EGFR

  • exon 2, 3, 4

mutauion in KRAS = unchcked growth

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8
Q

CRC- Pembrolizumab utility/mutation

A

MS1/MLH1/MSH2/MSH6/PMS2/CD274

when MSI-H or dMMR present

express PD-L1 (CD274) expression

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9
Q

CRC- nivolumab utility /mutation

A

MS1/MLH1/MSH2/MSH6/PMS2/CD274

when MSI-H and dMMR present

expresses PD-L1 (CD274) expression

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10
Q

what is the mnemonic for colorectal cancer drugs?

A

five
children
I
care
por
pass
nan

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11
Q

CRC what is the only pro-drug?

A

irinotecan

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12
Q

Lung Cancer - what are the KRAS mutation drugs?

A

Sotorasib and Adagraside

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13
Q

Lung Cancer - Sotorasib utility/mutation

A

KRAS mutation in G12C

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14
Q

Lung Cancer - Adagrasib utility/mutation

A

KRAS - G12c mutation

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15
Q

Lung Cancer - what are the EGFR drugs?

A

Geftitinib
Erlotinib
Afatinib
Docomitinib
Osimertinib
Mobocertinib

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16
Q

Lung Cancer - gefitinib mutation/utility

A

EGFR
- exon 19 deletion or exon 21 substituion
- not effective against exon 20 mutation

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17
Q

Lung Cancer - Erlotinib mutation/utility

A

EGFR
- exon 19 deletion, exon 21 substitution

not effective against exon 20 mutation

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18
Q

Lung Cancer - Afatinib mutation/utility

A

EGFR
- exon 19 deletion, exon 21 substitution

not effective against exon 20 mutation

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19
Q

Lung Cancer - dacomitinib mutation/utility

A

EGFR
- exon 19 deletion, exon 21 substitution

not effective against exon 20 mutation

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20
Q

Lung Cancer - osimertinib mutation/utility

A

EGFR
- exon 19 deletion, exon 21 substitution

EFFECTIVE against exon 20 mutation

21
Q

Lung Cancer - mobocertinib mutation/utility

A

EGFR

  • exon 20 insertion
22
Q

Lung cancer - what are the drugs associated with the ALK gene?

A

Crizotinib
Ceritinib
Ramucirumab
Lorlatinib
Alectinib
brigatinib

23
Q

Lung Cancer - Crizotinib mutation/utility

A

ALK /ROS1
- translocation of the ALK gene causing the expression of oncoproteins

24
Q

Lung Cancer -Ceritinib mutation/utility

A

ALK
-ALK gene translocation - expression of oncoproteins

25
Q

Lung Cancer - Ramtucirumab mutation/utility

A

EGFR /ALK

26
Q

Lung Cancer - Lorlatinib mutation/utility

A

ALK
-ALK gene translocation - expression of oncoproteins

27
Q

Lung Cancer - Alectinib mutation/utility

A

ALK
- Alk gene translocation - expression of oncoproteins

28
Q

Lung Cancer - brigatinib mutation/utility

A

ALK
- ALK gene translocation - expression of oncoproteins

29
Q

Lung Cancer - What is the mnemonic for ALK mutations?

A

CC (the) RLAB

30
Q

Lung Cancer - Entrectinib utility /mutation

A

ROS1/NTRK fusion

31
Q

Lung Cancer - Dabrafenib utility/mutaion and risk factor

A

BRAF V600E mutation and G6PD causes risk for hemolytic anemia

32
Q

Lung Cancer - MET mutation drugs

A

Capmatenib
Tepotinib

33
Q

Lung Cancer - Capmatinib utility/mutation

A

MET - causing exon 14 skipping mutation

34
Q

Lung Cancer - Tepotinib utility and mutation

A

MET - exon 14 skipping mutation

35
Q

Lung Cancer - drugs for the RET fusion gene

A

Selpercatinib and Palsetinib

36
Q

Lung Cancer - Selpercatinib utility/mutation

A

RET fusion

37
Q

Lung cancer - Pralsetinib utility/mutation

A

RET fusion

38
Q

Lung cancer - Drugs for CD274/EGFR/ALK or just EGFR/ALK

A

Pembrolizumab
Nivolumab
Atezolizumab
Cemiplimab
Durvalumab
Ipilimumab
Tremelimumab
Premetrexed

Ramucirumab

39
Q

Lung cancer - Pembrolizumab utility/mutation

A

CD274/EGFR/ALK

CD274 expression

without EGFR or ALK mutation

40
Q

Lung cancer - Nivolumab utility/mutation

A

CD274/EGFR/ALK

CD274 expression without EGFR/ALK mutation

41
Q

Lung cancer - Atzezolizumab utility/mutation

A

CD274/EGFR/ALK

PB-L1 (CD274) expression

w/o mutation in egfr/alk

42
Q

Lung cancer - cemiplimab utility/mutation

A

CD274/EGFR/ALK/Ros1

PB-L1 (CD274) expression

w/o mutation in egfr/alk/ros1

43
Q

Lung cancer - durvalumab utility/mutation

A

CD274/EGFR/ALK

PB-L1 (CD274) expression

w/o mutation in egfr/alk

44
Q

Lung cancer - ipilimumab utility/mutation

A

CD274/EGFR/ALK

PB-L1 (CD274) expression

w/o mutation in egfr/alk

45
Q

Lung cancer - Tremelimumab utility/mutation

A

EGFR/ALK

w/o mutation in egfr/alk

46
Q

Lung cancer - pemetrexed utility/mutation

A

EGFR/ALK

w/o mutation in egfr/alk

47
Q

Lung cancer - ramcirumab utility/mutation

A

ELK/ALK

48
Q

Lung cancer- what is the mnemonic for CD274/EGFR/ALK or just EGFR/ALK

A

Penguins
Nibble
Apples

(while)

Cats
Dance
In
The
Park

R

Gnemoics (6 decks)

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