Medical Oncology - CRC and lung cancer

Question 1

Drugs for colorectal cancer (CRC)

Answer 1

5-Floruracil
Capecitabine
Irinotecan
Cetuximab
Panitumumab
Pembrolizumab
Nivolumab

Question 2

CRC- 5- fluorouracil utility/mutations

Answer 2

DPD *2A - splicing mutation

DPD is needed for pyrimidine catabolism

Question 3

CRC - 5 fluorouracil IM and PM

Answer 3

IM: reduce dose by 50%

PM: don’t use

Question 4

CRC - capecitabine utility/mutation

Answer 4

DPD

DPD needed for pyrimidine catabolims

Question 5

CRC - irinotecan utility/mutation

Answer 5

UGT1A16/28 allele

causes reduced enzyme activity and toxicity

Question 6

CRC - cetuximab utility/ mutations

Answer 6

KRAS/NRAS/EGFR

• focus on exons 2, 3, 4

mutations in KRAS = unchecked growth

Question 7

CRC - panitumumab utility and mutaion

Answer 7

KRAS/NRAS/EGFR

• exon 2, 3, 4

mutauion in KRAS = unchcked growth

Question 8

CRC- Pembrolizumab utility/mutation

Answer 8

MS1/MLH1/MSH2/MSH6/PMS2/CD274

when MSI-H or dMMR present

express PD-L1 (CD274) expression

Question 9

CRC- nivolumab utility /mutation

Answer 9

MS1/MLH1/MSH2/MSH6/PMS2/CD274

when MSI-H and dMMR present

expresses PD-L1 (CD274) expression

Question 10

what is the mnemonic for colorectal cancer drugs?

Answer 10

five
children
I
care
por
pass
nan

Question 11

CRC what is the only pro-drug?

Answer 11

irinotecan

Question 12

Lung Cancer - what are the KRAS mutation drugs?

Answer 12

Sotorasib and Adagraside

Question 13

Lung Cancer - Sotorasib utility/mutation

Answer 13

KRAS mutation in G12C

Question 14

Lung Cancer - Adagrasib utility/mutation

Answer 14

KRAS - G12c mutation

Question 15

Lung Cancer - what are the EGFR drugs?

Answer 15

Geftitinib
Erlotinib
Afatinib
Docomitinib
Osimertinib
Mobocertinib

Question 16

Lung Cancer - gefitinib mutation/utility

Answer 16

EGFR
- exon 19 deletion or exon 21 substituion
- not effective against exon 20 mutation

Question 17

Lung Cancer - Erlotinib mutation/utility

Answer 17

EGFR
- exon 19 deletion, exon 21 substitution

not effective against exon 20 mutation

Question 18

Lung Cancer - Afatinib mutation/utility

Answer 18

EGFR
- exon 19 deletion, exon 21 substitution

not effective against exon 20 mutation

Question 19

Lung Cancer - dacomitinib mutation/utility

Answer 19

EGFR
- exon 19 deletion, exon 21 substitution

not effective against exon 20 mutation

Question 20

Lung Cancer - osimertinib mutation/utility

Answer 20

EGFR
- exon 19 deletion, exon 21 substitution

EFFECTIVE against exon 20 mutation

Question 21

Lung Cancer - mobocertinib mutation/utility

Answer 21

EGFR

• exon 20 insertion

Question 22

Lung cancer - what are the drugs associated with the ALK gene?

Answer 22

Crizotinib
Ceritinib
Ramucirumab
Lorlatinib
Alectinib
brigatinib

Question 23

Lung Cancer - Crizotinib mutation/utility

Answer 23

ALK /ROS1
- translocation of the ALK gene causing the expression of oncoproteins

Question 24

Lung Cancer -Ceritinib mutation/utility

Answer 24

ALK
-ALK gene translocation - expression of oncoproteins

Question 25

Lung Cancer - Ramtucirumab mutation/utility

Answer 25

EGFR /ALK

Question 26

Lung Cancer - Lorlatinib mutation/utility

Answer 26

ALK -ALK gene translocation - expression of oncoproteins

Question 27

Lung Cancer - Alectinib mutation/utility

Answer 27

ALK - Alk gene translocation - expression of oncoproteins

Question 28

Lung Cancer - brigatinib mutation/utility

Answer 28

ALK - ALK gene translocation - expression of oncoproteins

Question 29

Lung Cancer - What is the mnemonic for ALK mutations?

Answer 29

CC (the) RLAB

Question 30

Lung Cancer - Entrectinib utility /mutation

Answer 30

ROS1/NTRK fusion

Question 31

Lung Cancer - Dabrafenib utility/mutaion and risk factor

Answer 31

BRAF V600E mutation and G6PD causes risk for hemolytic anemia

Question 32

Lung Cancer - MET mutation drugs

Answer 32

Capmatenib Tepotinib

Question 33

Lung Cancer - Capmatinib utility/mutation

Answer 33

MET - causing exon 14 skipping mutation

Question 34

Lung Cancer - Tepotinib utility and mutation

Answer 34

MET - exon 14 skipping mutation

Question 35

Lung Cancer - drugs for the RET fusion gene

Answer 35

Selpercatinib and Palsetinib

Question 36

Lung Cancer - Selpercatinib utility/mutation

Answer 36

RET fusion

Question 37

Lung cancer - Pralsetinib utility/mutation

Answer 37

RET fusion

Question 38

Lung cancer - Drugs for CD274/EGFR/ALK or just EGFR/ALK

Answer 38

Pembrolizumab Nivolumab Atezolizumab Cemiplimab Durvalumab Ipilimumab Tremelimumab Premetrexed Ramucirumab

Question 39

Lung cancer - Pembrolizumab utility/mutation

Answer 39

CD274/EGFR/ALK CD274 expression without EGFR or ALK mutation

Question 40

Lung cancer - Nivolumab utility/mutation

Answer 40

CD274/EGFR/ALK CD274 expression without EGFR/ALK mutation

Question 41

Lung cancer - Atzezolizumab utility/mutation

Answer 41

CD274/EGFR/ALK PB-L1 (CD274) expression w/o mutation in egfr/alk

Question 42

Lung cancer - cemiplimab utility/mutation

Answer 42

CD274/EGFR/ALK/Ros1 PB-L1 (CD274) expression w/o mutation in egfr/alk/ros1

Question 43

Lung cancer - durvalumab utility/mutation

Answer 43

CD274/EGFR/ALK PB-L1 (CD274) expression w/o mutation in egfr/alk

Question 44

Lung cancer - ipilimumab utility/mutation

Answer 44

CD274/EGFR/ALK PB-L1 (CD274) expression w/o mutation in egfr/alk

Question 45

Lung cancer - Tremelimumab utility/mutation

Answer 45

EGFR/ALK w/o mutation in egfr/alk

Question 46

Lung cancer - pemetrexed utility/mutation

Answer 46

EGFR/ALK w/o mutation in egfr/alk

Question 47

Lung cancer - ramcirumab utility/mutation

Answer 47

ELK/ALK

Question 48

Lung cancer- what is the mnemonic for CD274/EGFR/ALK or just EGFR/ALK

Answer 48

Penguins Nibble Apples (while) Cats Dance In The Park R