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Gnemoics > CML > Flashcards

CML Flashcards

1
Q

CML - What are the drugs used to treat CML?

A

imitinib, nilotinib, bosutinib, dasatinib, ponatinib, asciminib

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2
Q

CML - what is their clinical utility overall? MOA

A

Affect BCR-ABL1
t(9;22) translocate to form Philadelphia chromosome which increases proliferation of leukemic cells

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3
Q

CML - Which ones can we use for the T315i mutation?

A

ponatinib, asciminib

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4
Q

CML - which drug has less toxicity associated with its use?

A

asciminib

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5
Q

CML - what is the funny mnemonic?

A

indeed new boobs do pop ahhh

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6
Q

CML - true or false these are all tyrosine tyrosine kinase inhibitors

A

true

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7
Q

CML - what phase of CML growth is each drug good for

A

Imitinib - CP , AP, BP
Nilotinib - CP, AP,
Bosutinib - CP, AP, BP
Dasatinib - CP, AP, BP
Panotinib - CP, AP, BP
Asciminib - CP

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8
Q

What does CML stand for?

A

chronic myeloid leukemia

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9
Q

What drugs are indicated for MDS?

A

imatinib
Lenalidomide

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10
Q

what does MDS stand for?

A

myelodysplastic syndrome

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11
Q

MDS- mutation/ clinical utility of imatinib

A

FIP1A1/PDGFRA
- gene alternation of PDGFRA

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12
Q

MDS- mutation/ clinical utility of lenalidomide

A

deletion of 5q on chromosome 5 making it shorter

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13
Q

what does AML stand for?

A

Acute myeloid leukemia

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14
Q

AML- what are the drugs used to treat it?

A

Midostaurin
Gilteritinib
Ivosidenib
Enasidenib
Gemtuzumab

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15
Q

AML- what gene is affected?

A

FIC gene

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16
Q

AML- what is the mutation for midostaurin

A

FLT3

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17
Q

AML- what is the mutation for gilteritinib

A

FLT3

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18
Q

AML- what is the mutation for ivosidenib

A

IHD1

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19
Q

AML- what is the mutation for enasidenib

A

IHD2

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20
Q

AML- what is the mutation for gemtuzumab

A

CD33

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21
Q

AML- what are the mutations in FLT3

A
  1. exon 14 ITD (inframe)
  2. point mutation in the kinase loop domain
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22
Q

AML- what is the mnemonic used / how many drugs

A

my gosh ivan eats grapes

5

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23
Q

drugs for APL?

A

arsenic trioxide and tretinoin

24
Q

What APL stands for?

A

Acute promyelocytic leukemia

25
Q

APL - mutaion/clinical utiliy

A

translocation of t(15;17) in PML/RARA genes

26
Q

APL- affects what genes specifically

A

PML/RARA

27
Q

CEL - what does it stand for

A

Chronic Eosinophilic leukemia

28
Q

CEL - treatment

A

imatinib

29
Q

CEL mutation/ clinical utility

A

FLIPA1A / PDGFRA
- gene re-arrangement in PDGFRA

30
Q

what does ASM stand for?

A

aggressive systemic mastocytosis

31
Q

ASM - treatment

A

imatinib

32
Q

ASM - caution point

A

not for the D816K mutation

33
Q

ASM - clinical utility/mutation

A

C- KIT

not for the D816V C-KIT mutation

34
Q

ALL - what does it stand

A

acute lymphoblastic leukemia

35
Q

ALL - What are the drugs?

A

Imatinib
Dasatinib
Ponatinib
Blinatumomab
Mercaptopurine
Vincristine

36
Q

ALL - what is the mnemonic

A

Icecream
delicious
pls
bring
me
vanilla

37
Q

ALL - what is the mutation or clinical utility of imatinib

A

BCR/ABL1 positive

38
Q

ALL - what is the mutation or clinical utility of dasatinib

A

BCR/ABL1 positive

39
Q

ALL - what is the mutation or clinical utility of ponatinib

A

BCR/ABL1 positive

40
Q

ALL - what is the mutation or clinical utility of Blinatumomab

A

BCR/ABL1 negative

41
Q

ALL - what is the mutation or clinical utility of vincristine

A

BCR/ABL1 negative

42
Q

ALL - what is the mutation or clinical utility of mercaptopurine

A

TPMT/NUDT15

TPMT 2/3A/3C = reduce enzyme actvity
NUDT 2/3 = PMs
NUDT 4/5/6 + IMs

43
Q

ALL - indicated for resistance to treatment or intolerance to treatment or new

A

Dasatinib

44
Q

ALL - indicated when no TKI other indicated

A

Ponatinib

45
Q

ALL - which drugs can be used for t315i mutations?

A

ponatinib

46
Q

CLL- drugs?

A

Ibrutinib and venetoclax

47
Q

CLL- mutation and clinical utility

A

deletion of 17p

48
Q

CLL- a drug with refractory of one prior treatment

A

venetoclax

49
Q

ALL - what drugs should be given alongside chemotherapy

A

imatinib, dasatinib, ponatinib

50
Q

what are the drugs for lymphomas?

A

rituximab
Denileukin Deftitox
Brentuximab Vedotin

51
Q

lymphomas - which drugs are for non-Hodgkins diffuse B-cell lymphoma?

A

rituximab

52
Q

lymphomas - which drugs are for Cutaneous T-cell lymphoma (CTCL)?

A

denileukin deftitox

53
Q

lymphomas - which drugs are for peripheral T-cell lymphoma (PTCL)?

A

brentuximab vedotin

54
Q

lymphomas - what is the clinical utility/mutation of rituximab?

A

CD20+

55
Q

lymphomas - what is the clinical utility/mutation of denileukin deftitox?

A

CD25 component of IL-2 receptor

56
Q

lymphomas - what is the clinical utility/mutation of brentuximab vedotin?

A

CD30

Gnemoics (6 decks)

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