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Gnemoics > Medical Oncology - breast cancer and > Flashcards

Medical Oncology - breast cancer and Flashcards

1
Q

Breast cancer - DPD drugs

A

5- fluorouracil and capecitabine

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2
Q

Breast cancer - 5- fluorouracil utility/mutation

A

DPD *2A

Splicing muation

presence reduces enzyme activity

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3
Q

Breast cancer - Capecitabine utility/mutation

A

DPD

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4
Q

ESR1/ESR2/CYD2D6

A

tamoxifen

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5
Q

ESR1/ESR2

A

Toremifene, and exemestane

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6
Q

ESR1/ESR2/PGR

A

anastrozole and letrozole

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7
Q

ESR1/ESR2/PGR/ERBB2

A

Fulvestrant
Everolimus
Palbociclib
Rabociclib
Trastuzumab
Pertuzumab
Neratinib

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8
Q

ESR1/ESR2/PGR/ERBB2/MK167

A

Abemaciclib (-)

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9
Q

ESR1/ESR2/PGR/ERBB2/PIK3CA

A

Alpelisib

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10
Q

ERBB2/BRCA1/BRACA2

A

olaparib, talazoparib (-)

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11
Q

ERBB2

A

Margetuximab and tucatinib (+)

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12
Q

ESR1/ESR2/PGR/ERBB2/HLA-DQA1/HLA-DRB1

A

Lapatinib (+)

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13
Q

ESR1/ESR2/PGR/ERBB2/CD274

A

Atezolizumab (-)

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14
Q

triple breat cancer

A

Atezolizumab (-)

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15
Q

What are the drugs for ovarian cancer?

A

olaparib
Rucaparib
Mirvertuximab

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16
Q

Ovarian cancer - clinical utility/mutation for olaparib?

A

BRCA1/BRCA2 - deleterious BRCA mutation

17
Q

Ovarian cancer - clinical utility/mutation for rucaparib?

A

BRCA1/BRCA2 - deleterious BRCA mutation

18
Q

Ovarian cancer - clinical utility/mutation for mirvertuximab?

A

FOLR1

19
Q

What are the drugs for endometrial cancer?

A

Dostarlimab
Lenvatinib

20
Q

Endometrial cancer - clinical utility/mutation for Dostarlimab?

A

MLH1/MSH2/MSH6/PMS2

  • dMMR and HSI-H present
21
Q

Endometrial cancer - clinical utility/mutation for lenvatinib?

A

MLH1/MSH2/MSH6/PMS2

-No dMMR or HSI-H present

22
Q

Melanoma - BRAF/KRAS/NRAS/HRAS drugs

A

*with BRAF V600E mutation

Vemurafenib
Dabrafenib
Encorafenib
Trametinib

23
Q

Melanoma - BRAF with BRAF V600E/K mutation drugs

A

Atezolizumab (also has CD274)
Binimetinib
Cobimetinib

24
Q

Melanoma - CD274 drugs

A

Pembrolizumab
Atezolizumab
Nivolumab

25
Q

urethial cancer - FGFR2/FGFR3/CYP2C9

A

erdatinib

26
Q

GI Stroma tumor - PDGFRA

A

avapritinib (exon 18 D842V MUTATION)

27
Q

Neuroendocrine Tumors - SSTR1/SSTR2/SSTR3/SSTR4/SSTR5

A

lutetium dotatate

28
Q

Cholangiocarcinoma - FGFR2 fusion

A

infigratinib

29
Q

solid tumor - NTRK1/NTRK2/NTRK3

A

larotrectinib

30
Q

solid tumor - VHL

A

belzutifan

31
Q

solid tumor - HLA*58:01

A

allopurinol

32
Q

solid tumor - G6PD

A

rasburicase

33
Q

Cholangiocarcinoma - FGFR2 fusion

A

pemigatinib

34
Q

Melanoma - HLA-A*0201

A

Tabentafusp

35
Q
A

Gnemoics (6 decks)

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