Medical Oncology - breast cancer and

Question 1

Breast cancer - DPD drugs

Answer 1

5- fluorouracil and capecitabine

Question 2

Breast cancer - 5- fluorouracil utility/mutation

Answer 2

DPD *2A

Splicing muation

presence reduces enzyme activity

Question 3

Breast cancer - Capecitabine utility/mutation

Answer 3

DPD

Question 4

ESR1/ESR2/CYD2D6

Answer 4

tamoxifen

Question 5

ESR1/ESR2

Answer 5

Toremifene, and exemestane

Question 6

ESR1/ESR2/PGR

Answer 6

anastrozole and letrozole

Question 7

ESR1/ESR2/PGR/ERBB2

Answer 7

Fulvestrant
Everolimus
Palbociclib
Rabociclib
Trastuzumab
Pertuzumab
Neratinib

Question 8

ESR1/ESR2/PGR/ERBB2/MK167

Answer 8

Abemaciclib (-)

Question 9

ESR1/ESR2/PGR/ERBB2/PIK3CA

Answer 9

Alpelisib

Question 10

ERBB2/BRCA1/BRACA2

Answer 10

olaparib, talazoparib (-)

Question 11

ERBB2

Answer 11

Margetuximab and tucatinib (+)

Question 12

ESR1/ESR2/PGR/ERBB2/HLA-DQA1/HLA-DRB1

Answer 12

Lapatinib (+)

Question 13

ESR1/ESR2/PGR/ERBB2/CD274

Answer 13

Atezolizumab (-)

Question 14

triple breat cancer

Answer 14

Atezolizumab (-)

Question 15

What are the drugs for ovarian cancer?

Answer 15

olaparib
Rucaparib
Mirvertuximab

Question 16

Ovarian cancer - clinical utility/mutation for olaparib?

Answer 16

BRCA1/BRCA2 - deleterious BRCA mutation

Question 17

Ovarian cancer - clinical utility/mutation for rucaparib?

Answer 17

BRCA1/BRCA2 - deleterious BRCA mutation

Question 18

Ovarian cancer - clinical utility/mutation for mirvertuximab?

Answer 18

FOLR1

Question 19

What are the drugs for endometrial cancer?

Answer 19

Dostarlimab
Lenvatinib

Question 20

Endometrial cancer - clinical utility/mutation for Dostarlimab?

Answer 20

MLH1/MSH2/MSH6/PMS2

• dMMR and HSI-H present

Question 21

Endometrial cancer - clinical utility/mutation for lenvatinib?

Answer 21

MLH1/MSH2/MSH6/PMS2

-No dMMR or HSI-H present

Question 22

Melanoma - BRAF/KRAS/NRAS/HRAS drugs

Answer 22

*with BRAF V600E mutation

Vemurafenib
Dabrafenib
Encorafenib
Trametinib

Question 23

Melanoma - BRAF with BRAF V600E/K mutation drugs

Answer 23

Atezolizumab (also has CD274)
Binimetinib
Cobimetinib

Question 24

Melanoma - CD274 drugs

Answer 24

Pembrolizumab
Atezolizumab
Nivolumab

Question 25

urethial cancer - FGFR2/FGFR3/CYP2C9

Answer 25

erdatinib

Question 26

GI Stroma tumor - PDGFRA

Answer 26

avapritinib (exon 18 D842V MUTATION)

Question 27

Neuroendocrine Tumors - SSTR1/SSTR2/SSTR3/SSTR4/SSTR5

Answer 27

lutetium dotatate

Question 28

Cholangiocarcinoma - FGFR2 fusion

Answer 28

infigratinib

Question 29

solid tumor - NTRK1/NTRK2/NTRK3

Answer 29

larotrectinib

Question 30

solid tumor - VHL

Answer 30

belzutifan

Question 31

solid tumor - HLA*58:01

Answer 31

allopurinol

Question 32

solid tumor - G6PD

Answer 32

rasburicase

Question 33

Cholangiocarcinoma - FGFR2 fusion

Answer 33

pemigatinib

Question 34

Melanoma - HLA-A*0201

Answer 34

Tabentafusp