medical marijuana Flashcards

1
Q

what are the rules for medicinal cannabis in the uk

A

Patients in the UK can be prescribed medicinal cannabis from today (1 Nov 2018), if it is agreed by a specialist doctor.

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2
Q

what initiated the change in laws on medicinal cannabis

A

It comes after a summer of campaigning by parents including Charlotte Caldwell, whose son Billy has severe epilepsy.

She went to Canada to procure the cannabis oil she says controls his seizures, but was not allowed to bring it back into the UK.

Her fight to keep the drug led to a policy review by home secretary Sajid Javid who brought in today’s law change after advice from experts on the Advisory Council on the Misuse of Drugs and the UK’s Chief Medical Adviser.

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3
Q

give an example of non-epilepsy patient helped

A

Other patients who have had to get their cannabis illegally up until now agree.

Faye Jones, from Reading, has rheumatoid arthritis and was put on strong chemotherapy drugs to control the pain.

Discovering cannabis, she said, was like “waving a magic wand” - and after being sofa-bound, she can now can get up, go to the gym, and hold down a successful career as an executive assistant.

But, she says, getting hold of the drug on the black market is “expensive and time consuming. Obviously I have to break the law to acquire my medicine.

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4
Q

give example of how it could harm patient safety having to get cannabis illegally

A

Carly Barton agrees. A fibromyalgia sufferer from Brighton, she found cannabis ended six years of intense and constant nerve pain.

“I’ve still been in some states, in agony in the dark, meeting people in parks,” she tells Sky News.

“Going to meet people I’ve never met before in abandoned industrial car parks. And in the middle of night in the dead of winter and I’m on a walking stick and I’ve got nothing to protect myself.

“I could handle myself, I could get out of a situation like that. But there are a lot of people a lot more vulnerable than I am, or was, being put in that situation.

“Hopefully some of those patients will be able to go to their doctors or go to the chemists where medicine belongs, and go to a place that’s safer for them to access.”

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5
Q

what do the new nhs england guidelines say

A

The new NHS England guidelines say doctors should only prescribe cannabis-based medicine if other options have been exhausted, for conditions including rare childhood epilepsy and multiple sclerosis as well as to help deal with nausea from chemotherapy drugs.

Only hospital specialists on the General Medical Council register will be able to write such prescriptions.

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6
Q

why might there be a lot of disappointed people

A

“But there’s a lot of people who aren’t under consultant care that won’t now have access. Two of the main reasons people use cannabis is for anxiety and depression, and they’re not likely to be under consultant care.

“They’re more likely just to be seeing their GP, and GPs won’t be able to prescribe cannabis based products. So I think there’s going to be a lot of disappointed people.”

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7
Q

how many people are affected by ms in the uk and what proportion of them could get relief from cannabis

A

“A lot of patients are going to want to access cannabis, they’re going to be sent to their specialist and the specialists are going to be inundated with requests. Really what the government needs to do is allows GPs to prescribe cannabis as well.”

The director for external affairs for MS Society UK, Genevieve Edwards, said: “Today should mark a key milestone for people with MS, which affects more than 100,000 of us in the UK.

“However we’re really concerned that nothing will change in the short term for the one in 10 people with MS who could get relief from pain and muscle spasms by using medicinal cannabis.

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8
Q

what did the home secretary say about the law change

A

Some are concerned that allowing medicinal cannabis could normalise the drug for recreational use.

The home secretary says this law change is to help “patients with an exceptional clinical need, but is in no way a first step to the legalisation of cannabis for recreational use.”

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9
Q

who can get access to medicinal cannabis

A

The treatments can be prescribed in cases of

Children with rare, severe forms of epilepsy
Adults with vomiting or nausea caused by chemotherapy
Adults with muscle stiffness caused by multiple sclerosis

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10
Q

which treatments will be prescribed

A

In practice, experts say this is likely to include pills, capsules and oils, but not smoking cannabis.

Treatments contain varying quantities and ratios of the compounds THC, which makes people feel “high”, and CBD, another compound scientists are investigating for its potential medical benefits.

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11
Q

how did we get to this point

A

The decision to allow specialist doctors to prescribe medicinal cannabis products follows the high-profile cases of Alfie seven, and Billy, 13.

Both have severe epilepsy which their families say has been markedly improved by cannabis oil treatments that had not been legally available in the UK.

Initially, the Home Office refused requests for a licence for Alfie to use the oil.

Billy’s mother, Charlotte, had cannabis oil that she brought back from Canada confiscated at Heathrow Airport.

Their plight prompted MPs to criticise the “bizarre and cruel” rules over medicinal cannabis.

The boys have since been granted special licences to access their treatments.

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12
Q

outline the progress to get to this point (i.e reviews)

A

The cases prompted Home Secretary Sajid Javid to announce in June that there would be a review of medicinal cannabis.

That review, which came in two parts, concluded there was evidence medicinal cannabis had therapeutic benefits and that doctors should be able to prescribe the products, provided they met safety standards.

In July Mr Javid confirmed that specialists doctors would be able to prescribe cannabis-derived medicinal products.

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13
Q

what were the rules before

A

Before today, almost all cannabis-based medicinal products were classed as Schedule One drugs, which means they were judged to have no therapeutic value. Sativex, a treatment containing the cannabis compounds THC and CBD, is one of the few that is already approved.

This meant these products could not be legally prescribed in the UK, and could be accessed only, in rare cases, with a special licence from the Home Office.

Now treatments that meet “appropriate standards” have been reclassified into Schedule Two - those that have a potential medical use.

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14
Q

what negative reactions have there been about the guidelines

A

Alfie Dingley’s mum, Hannah Deacon, said the guidelines meant people would struggle to access the oil her son had been given because scientific studies had not been carried out on the treatment.

“It’s absolutely gutting and not what my campaign was about.”

Emma Appleby, whose nine-year-old daughter, Teagan, has severe epilepsy, said it was not clear when she will receive medical cannabis.

She also said the guidelines suggested Teagan would be given a weaker form of treatment than doctors had initially suggested to her.

She said: “It’s heart-breaking to watch your child suffer every single day, knowing there’s a product that can help, could help…

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15
Q

what did the dr from ucl say

A

Dr Michael Bloomfield, from University College London, said the UK’s approach was sensible.

“It’s going to be very hard for doctors to prescribe cannabis-related products to begin with, and I think it’s right that’s the case.

“When we don’t have very strong evidence for any medicine, then it should be hard to prescribe something because we should be prescribing medicines when there’s a very strong evidence base for them.”

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16
Q

what are the rules for accessing cannabis for a child with epilepsy

A

The British Paediatric Neurology Association (BPNA) recommends that medical cannabis should be used as a ‘treatment of last resort’ for children who:

Have tried all the available licensed medicines for their type of epilepsy without success
Are either not suitable for the ketogenic diet, or have tried the ketogenic diet and it didn’t work
Are not suitable for epilepsy surgery
If a child meets all these criteria, the BPNA recommends prescribing the CBD-based medicine Epidiolex. The BPNA does not recommend prescribing cannabis oil or any form of medical cannabis other than Epidiolex. However, these are only recommendations, and it will be up to your child’s specialist to decide whether to prescribe medical cannabis and in what form.

The BPNA says only consultant paediatric neurologists should prescribe medical cannabis.

Even if a paediatric neurologist recommends medical cannabis for your child, the decision must be approved by the hospital. The NHS in your local area will also need to agree to pay for it.

17
Q

what are the rules for prescribing cannabis for adults with epilepsy

A

It’s likely that medical cannabis will only be considered as a treatment option for a very small number of adults. Specialists are likely to only recommend medical cannabis for adults with very severe epilepsy that started in childhood. And only when all other treatments have failed.

The Association of British Neurologists (ABN) has published guidelines on the use of cannabis-based products in neurology. It says specialists should only prescribe medical cannabis for adults diagnosed with Dravet syndrome or Lennox-Gastaut syndrome. These are both rare and severe forms of epilepsy.

18
Q

what do we know about the effectiveness of cannabis for epilepsy

A

Studies suggest that CBD may be an effective treatment for children with some types of hard-to-treat epilepsy. To assess how effective an epilepsy treatment is, researchers often look at how many people have a 50% or greater reduction in seizures. A recent evidence review found that one in every 8 people taking CBD would have a 50% or greater reduction in seizures. A much smaller number (less than 1 in 150) would become seizure free.

Patients have reported side-effects when taking CBD. Some of those reported were drowsiness, diarrhoea, reduced appetite and fatigue. Side-effects happen in around 1 in 3 people taking CBD.

19
Q

what happens if CBD is taken alongside epilepsy medicines

A

There’s some evidence that when CBD is taken alongside epilepsy medicines, the levels of the epilepsy medicines in the blood may be affected. With some medicines this can have potentially dangerous consequences. For example, people taking CBD with clobazam may have increased sedation, and people taking CBD with sodium valproate may have altered liver function.

20
Q

what don’t we know about the effectiveness of cannabis for epilepsy

A

Most studies have looked at medical cannabis as an ‘add-on’ therapy for people who are already taking a number of epilepsy medicines. This means we don’t know if medical cannabis works when taken on its own.

There haven’t been any studies comparing medical cannabis with other medicines already licensed for treating epilepsy. So we don’t know if medical cannabis is more or less effective than other epilepsy treatments. Neither do we know if it is more or less safe than other epilepsy treatments.

There’s also not enough evidence yet to say if products containing both CBD and THC are safe or effective. Neither is there evidence to say if the THC component is of any additional benefit. We do know, however, that THC does have a risk of additional side-effects.

As most studies have focused on children with specific types of hard-to-treat epilepsy, there’s not enough evidence to say if medical cannabis is useful for other people with epilepsy.

Most studies have used highly-regulated, ‘pharmaceutical grade’ CBD under medical supervision. We don’t know if unregulated CBD products (for example those available in health food shops) are safe or effective.

21
Q

what are the two most important parts of the cannabis plant, and how do they help epilepsy

A

The cannabis plant contains hundreds of natural chemicals. When looking at medical cannabis, the two most important are cannabidiol (CBD) and tetrahydrocannabinol (THC).

CBD does not have the mood-altering effects often associated with cannabis. There has been a lot of research into the potential of CBD as an epilepsy treatment.

THC is the part of the cannabis plant that makes people feel ‘high’. More research is needed to find out if products containing THC are safe or effective for treating epilepsy.

22
Q

What types of medical cannabis are available to treat epilepsy?

A

At the moment, there are no forms of medical cannabis licensed to treat epilepsy in the UK. A cannabis-based medicine called Epidiolex, containing CBD, is currently going through the licensing process. In the meantime, although it is unlicensed, specialists may prescribe it in rare circumstances.

There have been a small number of cases of children with severe epilepsy being prescribed unlicensed cannabis oil containing CBD and THC. It’s not clear at the moment how frequently this will be prescribed by specialists, but it’s likely to only be in very rare circumstances, where CBD alone hasn’t helped. This is because there is no clear evidence that THC is of additional benefit. And there is concern about its effect on brain development and mental health, particularly in children and young adults.

23
Q

what is multiple sclerosis

A

Multiple sclerosis (MS) is a condition that can affect the brain and/or spinal cord, causing a wide range of potential symptoms, including problems with vision, arm or leg movement, sensation or balance.

24
Q

symptoms of multiple sclerosis

A

fatigue
difficulty walking
vision problems, such as blurred vision
problems controlling the bladder
numbness or tingling in different parts of the body
muscle stiffness and spasms
problems with balance and co-ordination
problems with thinking, learning and planning
Depending on the type of MS you have, your symptoms may come and go in phases or get steadily worse over time (progress).