Medical Disorders Flashcards
Cognitive Phenotype
Cognitive Behavioral Profile associated with a brain disorder
Modal Profile
Most typical expression of a brain disorder
Variability
Expression of modal profile varies across individuals with disorder
Core Deficit
Cognitive deficit defined in terms of underlying process that is robust across variations in the modal profile
Challenge Level
There is variability across individuals in the amount of task demand/challenge that will elicit an observable deficit
Cognitive Phenocopies
Similar cognitive profiles that have different neurocognitive basis
Biological Insult
Cumulative severity of a disorder (severity of injury or disease
Genotype
The degree of genetic risk which either makes one susceptible for a disease and/or helps determine the severity of the disease
Environmental Toxicity
Teratogenic exposure that interferes with brain development. During critical periods it may negatively impact the ability currently under development
Brain Dysmorphologies
Abnormalities in brain development have implications for cognitive behavioral outcome
Primary Severity of Acquired Conditions
Cognitive morbidity associated with primary injury (traumatic brain injury)
Secondary Effects of Congenital & Acquired Conditions
Secondary Injury/varying trajectory of development. Cognitive morbidity is greater when secondary insult is added to a primary injury (TBI leading to hydrocephalus)
Treatment Morbidity
Treatments that worsen cognitive outsome to improve survival and/or functionality in a more vital domain (radiation
Reserve
Factors that lessen the effect of brain disease on cognitive outcome or in the absence of reserve, exacerbate the effect of disease on functioning
