Medical and Surgical Interventions Flashcards
Buproprion (Zyban)
Smoking cessation med
Antidepressant
Helps with withdrawal side effects
Varenincline (Chantix)
Partial nicotine receptor agonist
Helps prevent nicotine from stimulating receptors in the brain
Helps with withdrawal
Medications to Manage Secretions
Antitussives
Antihistamines
Decongestants
Mucolytics and Expectorants
Antitussives
Manages secretions
Cough medication
Suppresses cough reflex
Opioids also suppress this
Ex. hydrocodone, codeine... Could be in OTC cough suppressant meds Can be addictive Can build a tolerance Keep in mind that we need to get stuff out (minimize retainment of this)
Antihistamines
Manages secretions
Blocks histamine receptor
Some of these meds can cross BBB, so you can see CNS SEs (sedation, fatigue)
Ex. diphenhydramine (benadryl), cetirizine (zyrtec), loratadine (claritin)
Claritin
Decreases nasal decongestion
Decreases mucosal irritation
Zyrtec and Claritin
Don’t cross BBB
Decongestants
To manage secretions
Stimulates vasoconstriction in nasal vasculature
Often classified as alpha receptor agonists
Method of delivery affects side effects
Need to be aware of cardiovascular side effects
Ex. epenephrine (primatene), pseudoephedrine (sudafed)…
HA
Nausea
Nervousness
Can affect cardiac beta-1 receptors (arrhythmias, palpitations)
Mucolytics
Break up mucus in airway
Makes you want to cough
Expectorants
Facilitate mucus secretion and clearance
Makes you actually cough
Examples of Mucolytics and Expectorants
Mucomyst
Pulmozyme
Guaifenesin (Mucinex)
Beta-2 agonists
SHORT and LONG acting
Cause bronchodilation, relaxation of smooth mm by activating Beta 2 receptors and inhibit respiratory smooth mm contraction
Usually taken orally or inhaled (nebulizer, metered dose inhaler)
Albuterol
Salmetrol
Bronchodilators
Beta-2 agonists
Theophylline
Anticholinergics
Theophylline
Relaxes airway smooth mm, some anti-inflammatory effects
Usually taken orally, but can be injected
Xanthine derivative
Anticholinergics
Decrease ACh activity at various sites in the body, including the lungs… so inhibition of this facilitates bronchodilation
Limited use as not specific to the pulmonary system - may be used in combination with a beta-2 agonist
Atrovent
Spiriva
Anti-inflammatory medication
Corticosteroids - glucocorticoids
Leukotriene Modifiers
Cromones
Corticosteroids - glucocorticoids
Oral = prednisone, methylprednisone
Inhaled = triamcinolone (Asmacort), Flovent
Very effective at treating inflammation
Very useful in treatment of asthma
Steroid side effects
Steroid myopathy HTN Gastric ulcers Exacerbation of DM Steroid induced DM Glaucoma Adrenal gland suppression Osteoporosis Skin breakdown May have cushingoid look to face
Leukotriene Modifiers
Impact how leukotrienes work
Ex. Montelukast (singulair)
Leukotrienes
Lipid compound produced within cells lining respiratory mucosa that tend to augment the inflammatory response
Cromones
Help prevent inflammation in airway by inhibiting release of inflammatory mediators from cells in respiratory mucosa
Need to take BEFORE exposure to allergen/irritant
Help with prevention of an attack
Ex. Cromolyn (nasalcrom)
Cardiac affects in PT
Theophylline and beta-agonists
Corticosteroid effects PT
Thinning of skin and weakening of bones
Wedge resection
Remove a triangular-shaped tissue
Lung tumor removal
Bullectomy
Taking out bullae from emphysema patients
Lobectomy
Taking out one lobe of a lung
Pneumectomy
Removal of an entire lung
Lung Volume Reduction (LVRS)
Used to improve breathing in patients with severe emphysema
Lung transplant candidacy
Idiopathic pulmonary fibrosis COPD Cystic fibrosis Emphysema due to alpha-1-antitripsin deficiency Pulmonary arterial HTN Bronchiolitis obliterans Restrictive lung disease Pulmonary vascular disease
Absolute Criteria Lung Transplant
Normal other organ function
No malignancy for 2-5 years
Severe obstructive or restrictive disease
Limited life expectancy
No C/I to immunosuppressants
Ineffective or unavailable medical therapy
Relative criteria
Case by case basis
No resistant organisms
Ambulatory with rehab potential
No current alcohol, smoking, substance abuse
Absolute C/I Lung Transplant
Recent malignancy
Active infection with HEP B or C
Active/recent cigarette smoking, drug, or alcohol abuse
Severe psychiatric illness
Noncompliance with medical care
Absence of consistent and reliable social netowrk
Relative C/I Lung Transplant
HIV infection
Significant extrapulmonary organ dysfunction
Obesity/underweight
Nutritional status
Age
Other co-morbidities
Lung Transplant Complications
Primary Graft dysfuncton
Airway complications (bronchial stenosis)
Infection
Acute rejection
Chronic allograft dysfunction due to bronchiolitis obliterans (edema within 72 hrs of transplant)
Lung Transplant Anti-Rejection Meds
Tacrolimus (Prograf) - causes tremors
Mycophenolate mofetil (MMF)
Glucocorticoids