Medical and Dental Issues of Alcohol Flashcards
How is alcohol processed in the body?
90% metabolised in the liver
2-5% excreted in sweat, urine or breath
Describe the blood alcohol concentration ratio
Peaks 1 hour after drinking on empty stomach
Declines over next 24 hours
Removed at a rate of 15mg/100ml/hr
What are the genetic factors of alcohol problems?
4x increased risk of alcoholism in relatives
More common in monozygotic twins
Adopted away children of alcoholics 4x increased risk
What is the safe weekly limit of alcohol?
14 units per week
Spread over 3 or more days
Give examples of problems can be seen in the GI tract from chronic heavy drinking
GI bleeding
Acute gastritis
Oral, oesophageal, stomach, bowel cancer
Give examples of heart problems that can be seen from chronic heavy drinking
Cardiomyopathy
Cardiac arrhythmias
Hypertension
Give examples of skin, muscle, nerve and bone issues associated with chronic heavy drinking
Acute or chronic myopathy
Osteoporosis
Osteomalacia
Give examples of oral problems seen in chronic heavy drinking
Sialosis - salivary gland enlargement
Xerostomia
Poor wound healing and osteomyelitis
Suppression of immune system by alcohol
Erosion
Bruxism
What percentage of alcoholics will develop liver disease?
20%
What are the signs of liver disease?
Jaundice
Ascites
Bleeding
Infections
Encephalopathy
What is the life expectancy of alcohol related liver disease and liver cancer?
5 year survival is 90% if they stop drinking
60 if they don’t stop
Liver cancer - death in most within 10 years
What are the complications of liver disease?
Reduced synthesis of clotting factors
Reduced absorption of vitamin K
Platelet aggregation reduced
Prolonged bleeding
How does liver damage affect drug metabolism?
Reduces drug metabolism
Includes LA, analgesia, sedatives and antibiotics
How does having hep C affect alcoholics?
25% of hep C patients develop cirrhosis
Alcohol leads to more rapid development of liver disease
Patients with hep C should abstain from alcohol completely
What happens if alcohol is taken in combination with illegal drugs?
Cannabis - increased sensation of confusion and disorientation making accidents more likely
Amphetamines - increased impairment of judgement
Ecstasy - alcohol will reduce the potentially fatal fluid retention effect of ecstasy