Mediators of Inflammation

Question 1

coined the term “complement”

Answer 1

Paul Erlich

Question 2

Erlich defined “complement” as

Answer 2

the activity of blood serum that completes the action of antibody.

Question 3

What is complement? “refers to group of…”

Answer 3

refers to a group of more than 30 circulating and membrane-bound regulatory and constitutive component glycoproteins that functions: 1. to promote host defense against infectious agents 2. to promote the clearance of apoptotic cell debris and immune complexes 3. to regulate the immune response.

Question 4

the complement system functions to - 2

Answer 4

identify foreign cells micro-organisms and destroy them

Question 5

3 ways complement system destroys foreign cells and microorganisms

Answer 5

1. direct lysis 2. opsonization 3. inflammation

Question 6

Three (3) major complement activation pathways are present in human serum:

Answer 6

1. The Classical Pathway 2. The Alternative Pathway 3. The MBL Pathway (MB Lectin Pathway)

Question 7

In the classical pathway, (binding pathway) antigen–antibody complexes…

Answer 7

antigen–antibody complexes sequentially bind and activate C1, C4, and C2

Question 8

In the Alternative Pathway goes from

Answer 8

from C3 by the surface of microbe

Question 9

The MBL Pathway (MB Lectin Pathway) goes from

Answer 9

from C4 and C2 by the binding of MBL to mannose surface of microbes