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Patho > Mediators Of Inflammation > Flashcards

Mediators Of Inflammation Flashcards

1
Q

What type of enzyme is an acid hydrolase?

A

Lysosomal enzyme

Acid hydrolases are enzymes found in lysosomes that break down various biomolecules.

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2
Q

Which enzyme is responsible for killing bacteria?

A

Myeloperoxidase

Myeloperoxidase is an enzyme found in azurophilic granules that helps kill bacteria.

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3
Q

What is the primary function of cathepsin?

A

Protein degradation

Cathepsins are proteolytic enzymes involved in protein degradation.

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4
Q

What is the role of defensins?

A

Antimicrobial activity

Defensins are small peptides that exhibit antimicrobial activity.

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5
Q

What enzyme is released from tertiary granules?

A

Gelatinase

Gelatinase is a type of matrix metalloproteinase that degrades gelatin and collagen.

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6
Q

What special stain is used for mast cells and basophils?

A

Toluidine Blue

Toluidine Blue is a dye used to identify mast cells and basophils in tissue samples.

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7
Q

What type of chemokine is IL-8?

A

CXC chemokine

IL-8 is a CXC chemokine that attracts neutrophils to sites of inflammation.

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8
Q

Which chemokine attracts eosinophils?

A

Eotaxin

Eotaxin is specifically involved in attracting eosinophils during allergic reactions.

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9
Q

What is the primary function of RANTES?

A

Attracts T cells

RANTES is a chemokine that plays a role in recruiting T cells to sites of inflammation.

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10
Q

What do the letters in C-C chemokines represent?

A

Cysteine and any other amino acid

C-C chemokines have two adjacent cysteine residues, which are crucial for their function.

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11
Q

Which cytokines are known to decrease appetite?

A

IL-1 and TNF-alpha

IL-1 and TNF-alpha are pro-inflammatory cytokines that can lead to decreased appetite.

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12
Q

What is the role of Platelet-Activating Factor (PAF)?

A

Vasodilation and platelet aggregation

PAF is involved in promoting vasodilation and facilitating platelet aggregation.

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13
Q

What is the function of IL-6

A

Regulates acute phase reactants

IL-6 plays a significant role in the acute phase response, affecting levels of reactants.

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14
Q

True or False: Gelatinase is released by primary granules.

A

False

Gelatinase is actually released by tertiary granules, not primary granules.

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15
Q

Which interleukin is involved in T cell maturation?

A

TGF-beta

TGF-beta is crucial for T cell maturation and regulation.

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16
Q

Fill in the blank: _______ attracts monocytes and macrophages.

A

MCP

MCP (Monocyte Chemoattractant Protein) is involved in the recruitment of monocytes and macrophages.

Patho (6 decks)

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