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Patho > Kidney Nephrotic Nephritic > Flashcards

Kidney Nephrotic Nephritic Flashcards

1
Q

What is the immunofluorescence pattern associated with Good Pasteur’s syndrome?

A

Linear

Good Pasteur’s syndrome (RPGN)

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2
Q

What immunofluorescence pattern is seen in PSGN in children?

A

Granular IgG

PSGN (kids), Membranous (Elderly)

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3
Q

What immunofluorescence pattern is associated with Berger’s disease?

A

Granular IgA in mesangium

Berger’s disease

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4
Q

What is the immunofluorescence pattern seen in Lupus Nephritis?

A

Full house effect

Lupus Nephritis

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5
Q

What characterizes Pauci-immune conditions?

A

No deposits

Wegner’s, mPA (ca)

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6
Q

What are the symptoms of Nephritic Syndromes?

A

Inflammation present, hence Nephritic

Cola colored urine /dysmorphic RBCs/ RBC Casts / Hematuria / oliguria / hypertension

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7
Q

When does PSGN typically occur after pharyngitis?

A

10-21 days after pharyngitis

PSGN

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8
Q

What are the characteristics of PSGN?

A

Glomerular proliferation, Sub-epithelial humps

C3 and IgG on immunofluorescence

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9
Q

What is the immunofluorescence pattern seen in Berger’s Disease?

A

Mesangial proliferation, IgA in mesangium

Also known as IgA nephritis

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10
Q

What defines RPGN?

A

Cresentric glomeruli, Complication of PSGN (< 5%)

Usually immune-mediated (ANCAs, anti-GBM, ANA)

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11
Q

What are crescents in RPGN made up of?

A

Proliferated epithelial cells and WBCs

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12
Q

What characterizes Nephrotic Syndromes?

A

Proteinuria >3g/day, frothy urine

Destruction of GBM | Maltese cross in urine (also seen in Fabry’s disease)

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13
Q

What is Minimal Change Disease also known as?

A

Lipoid Nephrosis

No changes seen on light microscopy

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14
Q

What is seen in FSGS?

A

<50% of glomeruli affected

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15
Q

What are the types of Membranoproliferative Glomerulonephritis (MPGN)?

A

Type 1: Thick GBM, Hepatitis B/C

Tram track appearance; Type 2: Dense deposits

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16
Q

What is associated with Membranous Nephropathy in the elderly?

A

Adenocarcinoma (lung/colon) and melanoma

Antibodies against Phospholipase A2 receptors

17
Q

What is the appearance of Membranous Nephropathy on electron microscopy?

A

Sub epithelial Spike and Dome

18
Q

What is the first-line treatment for Steroid Resistant Nephrotic Syndrome (SRNS)?

A

Tacrolimus

19
Q

What is seen in Kimmelsteil Wilson Disease?

A

Nodular Glomerulosclerosis

PAS (+) and seen in Diabetic nephropathy

20
Q

What are the symptoms of Atheroembolic disease?

A

Fever + Rash + Allergic Intestinal Eosinophilia

Associated with Drugs, NSAIDs

21
Q

Subepithelial deposits are seen in

A

PSGN MGN

22
Q

Sub endothelial deposts

A

MPGN 1 wire loop lesions

Patho (6 decks)

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