Mediatiors of inflammation and Anti Inflammatory Drugs

Question 1

sources of histamine

Answer 1

mast cells
basophils
platelets

Question 2

sources of serotonin

Answer 2

platelets

Question 3

sources of prostaglandings

Answer 3

mast cells

leukocytes

Question 4

sources of leukotrienes

Answer 4

mast cells

leukocytes

Question 5

sources of PAF

Answer 5

leukocytes

mast cells

Question 6

sources of ROS

Answer 6

leukocytes

Question 7

sources of NO

Answer 7

endothelium

macrophages

Question 8

sources of cytokines (TNF, IL1, IL6)

Answer 8

macrophages
endothelial cells
mast cells

Question 9

sources of chemokines

Answer 9

leukocytes

activated macrophages

Question 10

sources of complement

Answer 10

plasma (produced in liver)

Question 11

sources of kinins

Answer 11

plasma (produced in liver)

Question 12

sources of proteases activated during coagulation

Answer 12

plasma (produced in liver)

Question 13

actions of histamine

Answer 13

vasodilation
increased vascular permability
endothelial activation

Question 14

action of serotonin

Answer 14

vasoconstriction

Question 15

action of prostaglandins

Answer 15

vasodilation
fever
pain

Question 16

action of leukotrienes

Answer 16

increased vascular permability
chemotaxis
leukocyte adhesion and activation

Question 17

action of PAF

Answer 17

vasodilation
increased vascular permeability
chemotaxis
leukocyte adhesion and activation

Question 18

action of ROS

Answer 18

killin of microbes

tissue damage

Question 19

action of NO

Answer 19

vascular smooth muscle relaxation

killing of microbes

Question 20

action of cytokines (TNF IL4, IL6)

Answer 20

Local: endothelial activation (ncreased exression of adhesion molecules)
Systemic: fever, metabolic abnormalities, hypotension and SHOCK

Question 21

action of chemokines

Answer 21

chemotaxis

leukocyte activation

Question 22

action of complement

Answer 22

leukocyte chemotaxis and activation
direct target killing (MAC),
vasodilation (mast cell stimulation IgE)

Question 23

action of kinins

Answer 23

increased vascular permeability
smooth muscle contraction
vasodliation
pain

Question 24

action of proteases active curing coagulation

Answer 24

endothelial activation

leukocytes recruitment

Question 25

eicosanoids that cause vasodilation

Answer 25

PGI2, PGE2, PGD2

Question 26

Eicosanoids causing vasoconstriction

Answer 26

thromboxane A2, LTC4, LTD4, LTE4

Question 27

eiocsanoids causing increase vascular permeability

Answer 27

LTC4, LTD4, LTE4

Question 28

eicosanoids causing chemotaxis and leukocyte adhesion

Answer 28

LTB4, HETE

Question 29

Major problem with NSAIDs and Corticosteroids

Answer 29

they are non-specific

Question 30

mitogen activated MAPk that is expressed in cells undergoing stress

Answer 30

p38

Question 31

Which cell expresses CTLA4 and what does it do?

Answer 31

T cell surface receptor that bind to the CD28 complex and turns second signal of activation OFF

Question 32

inflammatory mediators we currently have targets for

Answer 32

PG's, Histamine, C3a C5a, Lt's, CGRP (not effective yet), IL 1 and IlL6, TNF,LXA4 LXB4, LTB4,