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CMOD > Mediatiors of inflammation and Anti Inflammatory Drugs > Flashcards

Mediatiors of inflammation and Anti Inflammatory Drugs Flashcards

1
Q

sources of histamine

A

mast cells
basophils
platelets

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2
Q

sources of serotonin

A

platelets

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3
Q

sources of prostaglandings

A

mast cells

leukocytes

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4
Q

sources of leukotrienes

A

mast cells

leukocytes

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5
Q

sources of PAF

A

leukocytes

mast cells

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6
Q

sources of ROS

A

leukocytes

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7
Q

sources of NO

A

endothelium

macrophages

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8
Q

sources of cytokines (TNF, IL1, IL6)

A

macrophages
endothelial cells
mast cells

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9
Q

sources of chemokines

A

leukocytes

activated macrophages

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10
Q

sources of complement

A

plasma (produced in liver)

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11
Q

sources of kinins

A

plasma (produced in liver)

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12
Q

sources of proteases activated during coagulation

A

plasma (produced in liver)

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13
Q

actions of histamine

A

vasodilation
increased vascular permability
endothelial activation

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14
Q

action of serotonin

A

vasoconstriction

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15
Q

action of prostaglandins

A

vasodilation
fever
pain

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16
Q

action of leukotrienes

A

increased vascular permability
chemotaxis
leukocyte adhesion and activation

17
Q

action of PAF

A

vasodilation
increased vascular permeability
chemotaxis
leukocyte adhesion and activation

18
Q

action of ROS

A

killin of microbes

tissue damage

19
Q

action of NO

A

vascular smooth muscle relaxation

killing of microbes

20
Q

action of cytokines (TNF IL4, IL6)

A

Local: endothelial activation (ncreased exression of adhesion molecules)
Systemic: fever, metabolic abnormalities, hypotension and SHOCK

21
Q

action of chemokines

A

chemotaxis

leukocyte activation

22
Q

action of complement

A

leukocyte chemotaxis and activation
direct target killing (MAC),
vasodilation (mast cell stimulation IgE)

23
Q

action of kinins

A

increased vascular permeability
smooth muscle contraction
vasodliation
pain

24
Q

action of proteases active curing coagulation

A

endothelial activation

leukocytes recruitment

25
Q

eicosanoids that cause vasodilation

A

PGI2, PGE2, PGD2

26
Q

Eicosanoids causing vasoconstriction

A

thromboxane A2, LTC4, LTD4, LTE4

27
Q

eiocsanoids causing increase vascular permeability

A

LTC4, LTD4, LTE4

28
Q

eicosanoids causing chemotaxis and leukocyte adhesion

A

LTB4, HETE

29
Q

Major problem with NSAIDs and Corticosteroids

A

they are non-specific

30
Q

mitogen activated MAPk that is expressed in cells undergoing stress

A

p38

31
Q

Which cell expresses CTLA4 and what does it do?

A

T cell surface receptor that bind to the CD28 complex and turns second signal of activation OFF

32
Q

inflammatory mediators we currently have targets for

A

PG’s, Histamine, C3a C5a, Lt’s, CGRP (not effective yet), IL 1 and IlL6, TNF,LXA4 LXB4, LTB4,

CMOD (19 decks)

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