medgems

Question 1

thrombocytopenia
otherwise all normal in elderly women

Answer 1

immune thrombocytopenic purpura

> Destruction of platelets
autoimmune

Question 2

how to manage ITP?

Answer 2

steroids /IVIG

Question 3

diamond blackfan anaemia - blood count finding

Answer 3

anaemia
low reticulocyte
elevated foetal haemoglobin

Question 4

poikilocytotic erythrocytes in blood film with patient with myelofibrosis

Answer 4

dacrocyte

Question 5

pre treat chemo pts with?
to prevent?

Answer 5

IV allopurinol /rasburicase

Question 6

reversible agent for dabigtran?

Answer 6

Idarucizumab

Question 7

AML - buzz words

Answer 7

auer rods
blast
hepatomegaly

Question 8

AML subtype M3 management?

Answer 8

all trans retinoic acid

Question 9

all myeloproliferative syndromes can turn into?

Answer 9

acute myeloid leukaemia

Question 10

BCL2 inhibitor - lymphocyte apoptosis in CLL?

Answer 10

venetoclax

Question 11

cofactor in synthesis of protien C, S?

Answer 11

vitamin K

Question 12

Rare. 3x large than erythrocytes. Deep blue (basic) granules. Bilobed nucleus

Answer 12

basophil

Question 13

follicular lymphoma chromosomal translocation?

Answer 13

t(14:18)

Question 14

treatment for cancer that is t(9;22) BCR-ABL

Answer 14

imatinib
CML

Question 15

t911;14)

Answer 15

mantle cell lymphoma

Question 16

how does heparin work?

if severe bleed occurs is there antidote?

Answer 16

increasing the action of antithrombin III

protamine sulfate

Question 17

coeliac blood test?

Answer 17

anti tissue transglutaminase antibodiesw

Question 18

what does warfarin inhibit?

Answer 18

vit K epoxide reductase

Question 19

molecule secreted by liver inhibits iron absorption?

Answer 19

hepcidin

Question 20

where are auer rods found?

Answer 20

inside neutrophils
acute myeloid leukaemia

Question 21

sickle cell disease
glutamate substituted for?

Answer 21

valine
position 6 of beta chain
hbS

Question 22

PV rubra vera management?

Answer 22

phlebotomy
hydroxycarbamide

Question 23

what oncogene in burkitts

Answer 23

c-myc

Question 24

most common cause of b12 deficiency?

Answer 24

pernicious anaemia

Question 25

clusters of nuclear DNA within erythrocytes?

Answer 25

howell-jolly bodies

Question 26

how to raise plateelt count?

Answer 26

IVIG

Question 27

unfractionated heparin

Answer 27

(requires APTT monitoring)

Question 28

low platelet count how to manage?

Answer 28

Prenisolone

Question 29

heel prick test

Answer 29

Guthrie

Question 30

sickle cell pts what abx prophylaxis? to protect against?

Answer 30

penicillin
encapsualted - NHS

Question 31

warfarin reversal agent?

Answer 31

prothrombin complex concentrate

Question 32

Haemoglobin H disease

Answer 32

three defective alpha globin genes. Leads to chronic haemolytic anaemia - with associated splenomegaly

Question 33

beta thalassaemia

Answer 33

reduced, or absent, synthesis of the beta globin chain of haemoglobin

Question 34

Give an example of a treatment which increases fetal haemoglobin synthesis and hence can be used to reduce the severity of sickle cell disease or beta thalassaemia

Answer 34

Hydroxycarbamide

Question 35

alternative forms of haemoglobin that don;t use beta chjain?

Answer 35

HbA2 or Hb

Question 36

warfarin reversal agent?

Answer 36

Phytomenadione
vit k1

Question 37

sickle cell is abnormal?

Answer 37

beta globin chain

Question 38

inherited conditions that typically affect the synthesis of the globin chain in the haemoglobin protein

Answer 38

thalassaemia

Question 39

what coagulation factor decreases when starting warfarin

Answer 39

protein c and protein s