Med chem Part 1

Question 1

Which receptors are presynaptic?

(a1, a2, B1, B2) ?

Answer 1

a2 = presynaptic

Question 2

Which receptors are postsynaptic?

(a1, a2, B1, B2) ?

Answer 2

a1, B1, B2

Question 3

Fill in the blank

Signal –> a1 —> ____________–> smooth muscle contraction

Answer 3

phospholipase C

Question 4

Fill in the blank

Signal –> a2 –/–> ______ –> smooth muscle contraction

Answer 4

adenylyl cyclase –> doesnt receive signal and cant contract smooth muscle

Question 5

Adrenergic receptor agonists

For epinephrine, the C-1 hydroxyl must be in a ___ configuration for ______ activity for 3-point attachment to B-adrenergic

Answer 5

R configuration

direct activity

Question 6

Adrenergic receptor agonists

All agents are ______ charged (pka 8.5-10) so they are _____ (basic or acidic)

Answer 6

positively charged

basic

Question 7

Adrenergic receptor agonists

Determine the agonist responses in descending order of potency (greatest to least)
for alpha and beta

epinephrine, isoproterenol, norepinephrine

Answer 7

a) epinephrine > norepinephrine > isoproternol
b) isoproterenol > epinephrine >/= norepinephrine

epinephrine contains methyl,
norephrineprin contains Hydrogen
isoproterenol contains isopropyl