Med chem - Metro, nitro, oxazolidineones, glycopeptides

Question 1

4 nitroimidazoles and what are they used for

Answer 1

metronidazole
tinidazole
secnidazole
benznidazole

originally, used for vaginal infections (caused by trichomonas vaginalis) BUT shown to be effective for amebiasis, giardiasis, and ANAEROBIC BACTERIAL INFECTIONS (including c diff!!!)

Question 2

c diff is aerobic or anaeorbic

Answer 2

OBLIGATE anaerobe

Question 3

MOA nitrofurantoin

Answer 3

taken intracellularly by bacterial flavoproteins. reduces nitrofurantoin into reactive intermediates (including nitro radical!!)

these intermediates bind to bacterial ribosomes and inhibit bacterial enzymes that synthesize DNA, RNA, and cell wall proteins and other metabolic enzymes

Question 4

nitrofurantoin is ____ administered

Answer 4

orally

Question 5

what bacteria is nitrofurantoin effective against

Answer 5

most gram (+) and gran (-)

Question 6

is nitrifurantoin resistance common? why or why not?

Answer 6

RARE

because radicals are formed through bacterial bioreduction. bacteria can’t really stop this because they need reduction to survive

Question 7

name 6 oxazolidineones

Answer 7

linezolid
torezolid
tedizolid
radezolid
posizolid
eperezolid

Question 8

MOA oxazolidineones

Answer 8

bacteriostatic protein synthesis inhibitors by binding 30s, 50s, subunit

Question 9

uses of linezolid

Answer 9

nosocomial infections caused by MRSA and VRE