Mechanism of Actions

Question 1

Modifies mRNA synthesis, binds to estrogen receptors in the cell, dimerize and bind DNA, infleunces gene transcription….

…. is the MOA for what class(es) of medications?

Answer 1

Estrogens

Progestins

Question 2

Are estrogens or progestins primarily responsible for the contraceptive effect in OCPs?

Answer 2

Progestins

Question 3

Does estrogens or progestins stabilize the endometrium?

Answer 3

Estrogens

Question 4

Do estrogens or progestins inhibit FSH release?

Answer 4

Estrogens

Question 5

Do estrogens or progestins thicken cervical mucus?

Answer 5

Progestins

Question 6

Selective progesterone modulator, inhibits folliculogensis, reduces estradiol concentration, and delays follicular rupture……

…..is the MOA for what emergency contraception?

Answer 6

Ulipristal Acetate

Question 7

Inhibiting and delaying ovulation and preventing fertilization…..

…..is the MOA of what emergency contraception?

Answer 7

Levonorgestrel

Question 8

Progesterone and cortisol receptor antagonist without effects on estrogen receptors…..

…..is the MOA for what emergency contraception?

Answer 8

Mifepristone

Question 9

5HT receptor agonist at 5HT1A, antagonist at 5HT2a-C and dopamine receptors…..

….. is the MOA for this HRT drug?

Answer 9

Flibanserin (Addyi)

Question 10

Selective estrogen receptor modulators…. antagonist in breast tissue and agonist in the endometirum, bone, liver, and coagulation system….

….is the MOA for this Breast CA treatment?

Answer 10

Tamoxifen
Toremifene
Raloxifene

Question 11

Selective estrogen receptor down regulator which inhibits and degrades estrogen receptors…..

…. is the MOA for this Breast CA treatment?

Answer 11

Fulvestrant (Faslodex)

Question 12

Inhibit aromatase which is in high concentrations in breast cancer cells…..

…. is the MOA for what Breast CA treatment?

Answer 12

Anastrozole
Letrozole
Exemestane

Question 13

Inhibit phosphodiesterase-5 found in genital tissue, increase smooth muscle relaxation, and incease blood flow……

…. is the MOA for what ED treatment medications?

Answer 13

Sildenafil (Viagra)
Vardenafil (Levitra)
Tadalafil (Cialis)

Question 14

Block NE effects on alpha-1 receptors to help relax the prostate and urethra…

… is the MOA for what BPH medications?

Answer 14

Terazosin (Hytrin)
Doxazosin (Cardura)
Prazosin (Minipres)

Tamsulosin (Flomax)
Alfuzosin (Uroxatral)
Silodosin (Rapaflo)

Question 15

Blocks the conversion testosterone to dihydrotestosterone, block alpha-5 reductase….

…. is the MOA for what BPH medications?

Answer 15

Finasteride (Proscar)

Dutasteride (Avodart)

Question 16

Non-selective muscarinic receptor antagonists at M2 and M3…

… is the MOA for what OAB medications?

Answer 16

Oxybutynin (Ditropan)
Tolterodine (Detrol) 
Fesoterodine
Trospium
Solifenacin
Darifenacin (Enablex)

Question 17

Beta-3 agonist that works to relax the detrusor muscle and increase bladder capacity…..

… is the MOA for what OAB medication?

Answer 17

Mirabegron

Question 18

Blocks sodium channel with fast inactivation of action potentials….

…. is the MOA of what AED?

Answer 18

Carbamazepine (Tegretol)

Question 19

MDH metabolite that inhibits voltage-sensitive sodium channels….

…. is the MOA for what AED?

Answer 19

Oxcarbazepine (Trileptal)

Question 20

Blocks voltage-dependent sodium channels at high firing frequencies, Enhances H current, Modulates kainate receptors….

…. Is the MOA for what AED?

Answer 20

Lamotrigine (Lamictal)

Question 21

Believed to enhance GABA transmission, inhibit sodium channels, and modulate T-type Ca2+ channels…

… is the MOA for what AED?

Answer 21

Valproic Acid (Depakote)

Question 22

Binds reverisble SV2a, modulates kainate receptor activity, reverses inhibition of GABA and glycine gated currents induced by negative allosteric modulators…..

… is the MOA of what AED?

Answer 22

Levetiracetam (Keppra)

Question 23

Blocks voltage-dependent Na+ channels at high firing frequencies, increases frequency at which GABA opens Cl- channels, antagonizes glutamate action, inhibits carbonic anhydrase……

…. is the MOA of what AED?

Answer 23

Topiramate (Topamax)

Question 24

Blocks, low threshold, T-type calcium channels in thalamic neurons….

…. is the MOA of what AED?

Answer 24

Ethosuximide

Question 25

Slows the recovery of Na+ channels….

… is the MOA for what AED?

Answer 25

Phenytoin

Fosphenytoin

Question 26

Blocks voltage-dependent sodium and t-type calcium channels…

…. is the MOA of what second-line AED?

Answer 26

Zonisamide

Question 27

Enhances slow inactivation of voltage gated sodium channels…..

…. is the MOA of what second-line AED?

Answer 27

Lacosamide (Vimpat)

Question 28

Non-competitive glutamate receptor antagonist…..

… is the MOA for what second-line AED?

Answer 28

Perampanel

Question 29

Prolong GABA-mediated chloride channel opening…..

… is the MOA for what AED(s)?

Answer 29

Phenobarbital

Primidone

Question 30

Increase the frequency of GABA-mediated chloride channel openings, prolongs inhibitory post-synaptic currents….

… is the MOA for what AEDs?

Answer 30

Clonazepam (Klonopin)
Diazepam (Valium)
Lorazepam (Ativan)
Midazolam (Versed)

Question 31

Structurally related to GABA, blocks Ca2+ channels, enhances H current, supresses presynaptic vescile release, supresses NMDA receptors…..

… is the MOA for what AED?

Answer 31

Gabapentin (Neurontin)

Pregabalin (Lyrica)

Question 32

Interferes with GABA re-uptake site by binding to the uptake carrier….

… is the MOA for what AED?

Answer 32

Tiagabine (Gabitril)

Question 33

Irreversible inhibits GABA-transaminase….

…. is the MOA for what AED?

Answer 33

Vigabatrin

Question 34

Opens K+ channels….

….. is the MOA for what AED?

Answer 34

Ezogabine

Question 35

Blocks voltage-dependent Na+ channels, blocks NMDA receptors and enhances GABA receptors…..

…. is the MOA for what AED?

Answer 35

Felbamate (Felbatol)