Mechanism of Actions Flashcards

1
Q

Modifies mRNA synthesis, binds to estrogen receptors in the cell, dimerize and bind DNA, infleunces gene transcription….

…. is the MOA for what class(es) of medications?

A

Estrogens

Progestins

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2
Q

Are estrogens or progestins primarily responsible for the contraceptive effect in OCPs?

A

Progestins

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3
Q

Does estrogens or progestins stabilize the endometrium?

A

Estrogens

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4
Q

Do estrogens or progestins inhibit FSH release?

A

Estrogens

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5
Q

Do estrogens or progestins thicken cervical mucus?

A

Progestins

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6
Q

Selective progesterone modulator, inhibits folliculogensis, reduces estradiol concentration, and delays follicular rupture……

…..is the MOA for what emergency contraception?

A

Ulipristal Acetate

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7
Q

Inhibiting and delaying ovulation and preventing fertilization…..

…..is the MOA of what emergency contraception?

A

Levonorgestrel

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8
Q

Progesterone and cortisol receptor antagonist without effects on estrogen receptors…..

…..is the MOA for what emergency contraception?

A

Mifepristone

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9
Q

5HT receptor agonist at 5HT1A, antagonist at 5HT2a-C and dopamine receptors…..

….. is the MOA for this HRT drug?

A

Flibanserin (Addyi)

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10
Q

Selective estrogen receptor modulators…. antagonist in breast tissue and agonist in the endometirum, bone, liver, and coagulation system….

….is the MOA for this Breast CA treatment?

A

Tamoxifen
Toremifene
Raloxifene

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11
Q

Selective estrogen receptor down regulator which inhibits and degrades estrogen receptors…..

…. is the MOA for this Breast CA treatment?

A

Fulvestrant (Faslodex)

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12
Q

Inhibit aromatase which is in high concentrations in breast cancer cells…..

…. is the MOA for what Breast CA treatment?

A

Anastrozole
Letrozole
Exemestane

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13
Q

Inhibit phosphodiesterase-5 found in genital tissue, increase smooth muscle relaxation, and incease blood flow……

…. is the MOA for what ED treatment medications?

A

Sildenafil (Viagra)
Vardenafil (Levitra)
Tadalafil (Cialis)

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14
Q

Block NE effects on alpha-1 receptors to help relax the prostate and urethra…

… is the MOA for what BPH medications?

A

Terazosin (Hytrin)
Doxazosin (Cardura)
Prazosin (Minipres)

Tamsulosin (Flomax)
Alfuzosin (Uroxatral)
Silodosin (Rapaflo)

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15
Q

Blocks the conversion testosterone to dihydrotestosterone, block alpha-5 reductase….

…. is the MOA for what BPH medications?

A

Finasteride (Proscar)

Dutasteride (Avodart)

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16
Q

Non-selective muscarinic receptor antagonists at M2 and M3…

… is the MOA for what OAB medications?

A
Oxybutynin (Ditropan)
Tolterodine (Detrol) 
Fesoterodine
Trospium
Solifenacin
Darifenacin (Enablex)
17
Q

Beta-3 agonist that works to relax the detrusor muscle and increase bladder capacity…..

… is the MOA for what OAB medication?

A

Mirabegron

18
Q

Blocks sodium channel with fast inactivation of action potentials….

…. is the MOA of what AED?

A

Carbamazepine (Tegretol)

19
Q

MDH metabolite that inhibits voltage-sensitive sodium channels….

…. is the MOA for what AED?

A

Oxcarbazepine (Trileptal)

20
Q

Blocks voltage-dependent sodium channels at high firing frequencies, Enhances H current, Modulates kainate receptors….

…. Is the MOA for what AED?

A

Lamotrigine (Lamictal)

21
Q

Believed to enhance GABA transmission, inhibit sodium channels, and modulate T-type Ca2+ channels…

… is the MOA for what AED?

A

Valproic Acid (Depakote)

22
Q

Binds reverisble SV2a, modulates kainate receptor activity, reverses inhibition of GABA and glycine gated currents induced by negative allosteric modulators…..

… is the MOA of what AED?

A

Levetiracetam (Keppra)

23
Q

Blocks voltage-dependent Na+ channels at high firing frequencies, increases frequency at which GABA opens Cl- channels, antagonizes glutamate action, inhibits carbonic anhydrase……

…. is the MOA of what AED?

A

Topiramate (Topamax)

24
Q

Blocks, low threshold, T-type calcium channels in thalamic neurons….

…. is the MOA of what AED?

A

Ethosuximide

25
Slows the recovery of Na+ channels.... ... is the MOA for what AED?
Phenytoin | Fosphenytoin
26
Blocks voltage-dependent sodium and t-type calcium channels... .... is the MOA of what second-line AED?
Zonisamide
27
Enhances slow inactivation of voltage gated sodium channels..... .... is the MOA of what second-line AED?
Lacosamide (Vimpat)
28
Non-competitive glutamate receptor antagonist..... ... is the MOA for what second-line AED?
Perampanel
29
Prolong GABA-mediated chloride channel opening..... ... is the MOA for what AED(s)?
Phenobarbital | Primidone
30
Increase the frequency of GABA-mediated chloride channel openings, prolongs inhibitory post-synaptic currents.... ... is the MOA for what AEDs?
Clonazepam (Klonopin) Diazepam (Valium) Lorazepam (Ativan) Midazolam (Versed)
31
Structurally related to GABA, blocks Ca2+ channels, enhances H current, supresses presynaptic vescile release, supresses NMDA receptors..... ... is the MOA for what AED?
Gabapentin (Neurontin) | Pregabalin (Lyrica)
32
Interferes with GABA re-uptake site by binding to the uptake carrier.... ... is the MOA for what AED?
Tiagabine (Gabitril)
33
Irreversible inhibits GABA-transaminase.... .... is the MOA for what AED?
Vigabatrin
34
Opens K+ channels.... ..... is the MOA for what AED?
Ezogabine
35
Blocks voltage-dependent Na+ channels, blocks NMDA receptors and enhances GABA receptors..... .... is the MOA for what AED?
Felbamate (Felbatol)