Mechanism of Actions Flashcards by Zachary Schulz

Modifies mRNA synthesis, binds to estrogen receptors in the cell, dimerize and bind DNA, infleunces gene transcription….

…. is the MOA for what class(es) of medications?

Estrogens

Progestins

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Are estrogens or progestins primarily responsible for the contraceptive effect in OCPs?

Progestins

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Does estrogens or progestins stabilize the endometrium?

Estrogens

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Do estrogens or progestins inhibit FSH release?

Estrogens

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Do estrogens or progestins thicken cervical mucus?

Progestins

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Selective progesterone modulator, inhibits folliculogensis, reduces estradiol concentration, and delays follicular rupture……

…..is the MOA for what emergency contraception?

Ulipristal Acetate

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Inhibiting and delaying ovulation and preventing fertilization…..

…..is the MOA of what emergency contraception?

Levonorgestrel

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Progesterone and cortisol receptor antagonist without effects on estrogen receptors…..

…..is the MOA for what emergency contraception?

Mifepristone

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5HT receptor agonist at 5HT1A, antagonist at 5HT2a-C and dopamine receptors…..

….. is the MOA for this HRT drug?

Flibanserin (Addyi)

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Selective estrogen receptor modulators…. antagonist in breast tissue and agonist in the endometirum, bone, liver, and coagulation system….

….is the MOA for this Breast CA treatment?

Tamoxifen
Toremifene
Raloxifene

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Selective estrogen receptor down regulator which inhibits and degrades estrogen receptors…..

…. is the MOA for this Breast CA treatment?

Fulvestrant (Faslodex)

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Inhibit aromatase which is in high concentrations in breast cancer cells…..

…. is the MOA for what Breast CA treatment?

Anastrozole
Letrozole
Exemestane

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Inhibit phosphodiesterase-5 found in genital tissue, increase smooth muscle relaxation, and incease blood flow……

…. is the MOA for what ED treatment medications?

Sildenafil (Viagra)
Vardenafil (Levitra)
Tadalafil (Cialis)

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Block NE effects on alpha-1 receptors to help relax the prostate and urethra…

… is the MOA for what BPH medications?

Terazosin (Hytrin)
Doxazosin (Cardura)
Prazosin (Minipres)

Tamsulosin (Flomax)
Alfuzosin (Uroxatral)
Silodosin (Rapaflo)

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Blocks the conversion testosterone to dihydrotestosterone, block alpha-5 reductase….

…. is the MOA for what BPH medications?

Finasteride (Proscar)

Dutasteride (Avodart)

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Non-selective muscarinic receptor antagonists at M2 and M3…

… is the MOA for what OAB medications?

Oxybutynin (Ditropan)
Tolterodine (Detrol) 
Fesoterodine
Trospium
Solifenacin
Darifenacin (Enablex)

Beta-3 agonist that works to relax the detrusor muscle and increase bladder capacity…..

… is the MOA for what OAB medication?

Mirabegron

Blocks sodium channel with fast inactivation of action potentials….

…. is the MOA of what AED?

Carbamazepine (Tegretol)

MDH metabolite that inhibits voltage-sensitive sodium channels….

…. is the MOA for what AED?

Oxcarbazepine (Trileptal)

Blocks voltage-dependent sodium channels at high firing frequencies, Enhances H current, Modulates kainate receptors….

…. Is the MOA for what AED?

Lamotrigine (Lamictal)

Believed to enhance GABA transmission, inhibit sodium channels, and modulate T-type Ca2+ channels…

… is the MOA for what AED?

Valproic Acid (Depakote)

Binds reverisble SV2a, modulates kainate receptor activity, reverses inhibition of GABA and glycine gated currents induced by negative allosteric modulators…..

… is the MOA of what AED?

Levetiracetam (Keppra)

Blocks voltage-dependent Na+ channels at high firing frequencies, increases frequency at which GABA opens Cl- channels, antagonizes glutamate action, inhibits carbonic anhydrase……

…. is the MOA of what AED?

Topiramate (Topamax)

Blocks, low threshold, T-type calcium channels in thalamic neurons….

…. is the MOA of what AED?

Ethosuximide

Slows the recovery of Na+ channels.... ... is the MOA for what AED?

Phenytoin | Fosphenytoin

Blocks voltage-dependent sodium and t-type calcium channels... .... is the MOA of what second-line AED?

Zonisamide

Enhances slow inactivation of voltage gated sodium channels..... .... is the MOA of what second-line AED?

Lacosamide (Vimpat)

Non-competitive glutamate receptor antagonist..... ... is the MOA for what second-line AED?

Perampanel

Prolong GABA-mediated chloride channel opening..... ... is the MOA for what AED(s)?

Phenobarbital | Primidone

Increase the frequency of GABA-mediated chloride channel openings, prolongs inhibitory post-synaptic currents.... ... is the MOA for what AEDs?

Clonazepam (Klonopin) Diazepam (Valium) Lorazepam (Ativan) Midazolam (Versed)

Structurally related to GABA, blocks Ca2+ channels, enhances H current, supresses presynaptic vescile release, supresses NMDA receptors..... ... is the MOA for what AED?

Gabapentin (Neurontin) | Pregabalin (Lyrica)

Interferes with GABA re-uptake site by binding to the uptake carrier.... ... is the MOA for what AED?

Tiagabine (Gabitril)

Irreversible inhibits GABA-transaminase.... .... is the MOA for what AED?

Vigabatrin

Opens K+ channels.... ..... is the MOA for what AED?

Ezogabine

Blocks voltage-dependent Na+ channels, blocks NMDA receptors and enhances GABA receptors..... .... is the MOA for what AED?

Felbamate (Felbatol)