Interactions / P450 Flashcards
Progesterone is metabolized by 3A4, and should be avoided with what anitfungal medication?
Ketaconazole
Rifampin _______ (Increase/decreases) OCP efficacy
decreases
Which THREE AEDs may decrease OCP efficacy?
What are THREE non-OCP contraceptive methods to prevent this?
- Carbamazepine
- Phenobarbital
- Phenytoin
Alternatives……
- IUD
- DMPA
- Implants
Which ABx potentially decrease ethinyl estradiol concentration?
Which ABx may cause breakthrough bleeding?
Tetracyclines and PCNs
Ampicillin
Is Mifepristone a P450 drug?
Yes
T/F: Tamoxifen is NOT a P450 drug?
False
What anticoagulant does Tamoxifen interact with?
Warfarin
Does Tamoxifen interact with ALL Aromatase inhibitors?
No, only…..
Anastrozole
Letrozole
Will Tamoxifen interact with Rifampin?
Yes
Is it okay to give Toremifene with drugs that may prolong a QT?
No
T/F: Fluvestrant interacts with P450 medications
False
It has NO P450 interactions
Why should nitrates be avoided when using PDE5 inhibitors to treat ED?
Increase in hypotension
Which PDE5 Inhibitor should be avoided with anti-arrhythmics due to an increased risked of QT prolongation?
Vardenafil
Why should diltiazem be avoided in patients taking Tamsulosin?
Tamsulosin decreases the metabolism of diltiazem
Which TWO AEDs reduce the effectiveness of Tamsulosin?
Phenytoin
Carbamazepine