MECHANISM OF ACTION Flashcards
1
Q
Mechanism of action of alkylating agents
A
Crosslinking of DNA, resulting in inhibition of DNA synthesis and function
2
Q
Mechanism of action of antimetabolites
A
Blocking synthesis of DNA and/or RNA
3
Q
Mechanism of action of cytotoxic antibiotics
A
Bind to DNA through intercalation between specific bases and block the synthesis of DNA, RNA or both
Inhibit activity of topoisomerase
4
Q
Mechanism of protein kinase inhibitors
A
Inhibit kinases involved in growth factor receptor transduction
5
Q
Mechanism of camptothecins
A
Inhibition of Topoisomerase
6
Q
Mechanism of Vinca alkaloids
A
Prevent microtubule assembly
Prevents spindle formation
7
Q
Mechanism of taxanes
A
Prevent microtubule assembly
Prevents spindle formation
8
Q
Mechanism of epipodophyllotoxins
A
Inhibition of Topoisomerase
