Mechanism of Action

Question 1

Mycophenolate Mofetil (CellCept)

Answer 1

Antimetabolite that inhibits T cell proliferation by alternating purine (A + G) synthesis

Question 2

Azathioprine

Answer 2

Antimetabolite that inhibits T cell proliferation by alternating purine (A + G) synthesis

Question 3

Tacrolimus (Prograf)

Answer 3

Block Signal 1 of T cell activation by inhibiting calcineurin

Question 4

Cyclosporine (Neoral, Gengraf, Sandimmune)

Answer 4

Calcineurin inhibitor that stops T cell activation by blocking signal 1

Question 5

Everlimus

Answer 5

Mammalian target of rapamycin (mTOR) inhibitor that inhibits the proliferation of T cells, therefore stopping activation

Question 6

Sirolimus

Answer 6

Mammalian target of rapamycin (mTOR) inhibitor that inhibits the proliferation of T cells, therefore stopping activation

Question 7

Belatacept

Answer 7

Binds to CD80 and CD86 on the APC to block them from binding to CD28 on the T cell to inhibit signal 2 of activation

Question 8

Orlistat (Xenical - Rx, Alli - OTC)

Answer 8

Decreases absorption of dietary fat by ~30%

**need to take fat soluable vitamins supplimentation (K, A, D, E) by separate by 2 hours
separate cyclosporine and levothyroxine

Question 9

Phentermine (Adipex-P)

Answer 9

appetitite suppression through stimulation the satiety center by releasing NE === stimulant!

Question 10

Naltrexone/Buproprion (Contrave)

Answer 10

Naltrexone = decreases food cravings
Buproprion = decreases appetite

Question 11

Topiramate

Answer 11

Increases satiety and decreases appetite; MOA not well known… could be by increase in GABA and blockade of glutamate receptors