Clinical Questions Flashcards
What is an allograft transplant?
When one individual donates an organ to another individual
What is an autograft transplant?
When the individual is his/her own donor
What blood type is the universal donor?
O type (no antigens, AB antibodies)
What blood type is the universal receiver?
AB type (AB antigens, no antibodies)
What drugs can be used for induction of immunosuppression?
Antithymocyte Globulin (Atgam, Thymoglobulin)
Basilixumab
What is the lymphocyte depleting agents?
Antithymocyte globulin (Atgam, Thymoglobulin)
What are the non-lymphocyte depleting agent for induction?
Basilixumab
What is the first line therapy for transplant immunosuppression maintenance?
CNI + antimetabolite
(Tacrolimus or Cyclosporine) + (Azathioprine or Mycophenolate)
What induction prophylaxis is the best option for patients at high risk for rejection?
Antithymocyte Globin (Atgam, Thymoclobulin) is the best option
What factors decrease you risk of transplant rejection?
Immunosuppression
Malignancy
Increased Age
What drugs should you avoid with CNI therapy?
Nephrotoxic agents, CYP3A4 inducers/inhibitors
What is the conversion between Cellcept and Myfortic?
Cellcept 500 mg = Myfortic 360 mg
What can be added to CNI + antimetabolite with initiate treatment if there is high risk for rejection?
Steroids (prednisone [deltasone]) needs to be added
A female patient with a liver transplant is needing maintenance therapy. What medication may increase mortality?
Tacrolimus ER should be avoided
A transplant patient with HTN, HLD, and gout is needing maintenance therapy. They are currently on rosuvastatin, lisinopril, and allopurinol. Which transplant therapy is contraindicated?
Azathioprine is contraindication
